# Silent Invader: The Enigmatic Case of Cardiac Angiosarcoma

**Authors:** FNU Arty, Devarashetty Shreya, Anoohya Vangala, Sankalp Acharya, Sai Rakshith Gaddameedi, Petro Vavrukh, Shazia M Shah

PMC · DOI: 10.7759/cureus.101480 · Cureus · 2026-01-13

## TL;DR

This paper presents a rare case of cardiac angiosarcoma that was difficult to diagnose due to its unusual symptoms and lack of typical signs.

## Contribution

The paper adds to the limited literature by describing a unique case with pleural metastasis and atypical presentation.

## Key findings

- The case involved primary cardiac epithelioid angiosarcoma with pleural metastasis.
- Symptoms included recurrent pericardial and pleural effusions without typical right atrial masses.
- Early biopsy and multidisciplinary evaluation are critical for timely diagnosis.

## Abstract

Cardiac angiosarcoma is a rare and aggressive malignant tumor that often masquerades as a more common cardiac condition. Patients frequently exhibit nonspecific symptoms, leading to delayed detection and a grim prognosis. Given the scarcity of documented cases, we present an intriguing case of primary cardiac epithelioid angiosarcoma with pleural metastasis, manifesting as recurrent pericardial and pleural effusions. This case highlights the diagnostic complexity of cardiac angiosarcoma, especially when typical right atrial masses are absent. Persistent, unexplained pericardial and pleural effusions should prompt consideration of malignancy, particularly when standard evaluations are inconclusive. Early tissue biopsy and a multidisciplinary approach are essential for the timely diagnosis and management of this rare but deadly condition.

## Full-text entities

- **Diseases:** cardiac condition (MESH:D006331), pleural metastasis (MESH:D009362), pericardial and pleural effusions (MESH:D010996), Cardiac Angiosarcoma (MESH:D006394), atrial masses (MESH:C536030), malignancy (MESH:D009369)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Full text

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## Figures

7 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12900983/full.md

## References

12 references — full list in the complete paper: https://tomesphere.com/paper/PMC12900983/full.md

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Source: https://tomesphere.com/paper/PMC12900983