# Leukocyte Chemotactic Factor 2 Amyloidosis (LECT‐2) Amyloidosis Case Report and Review of the Current Literature

## TL;DR

This paper reports a case of LECT-2 amyloidosis, a rare kidney disease, and reviews current knowledge about its diagnosis and presentation.

## Contribution

The novelty lies in highlighting the under-recognized nature of LECT-2 amyloidosis and its presentation as nephrotic-range proteinuria.

## Key findings

- LECT-2 amyloidosis can present with nephrotic-range proteinuria.
- Diagnosis is typically confirmed via kidney biopsy showing amyloid deposits.
- The condition is uncommon and often overlooked in clinical practice.

## Abstract

Amyloid deposition is an increasingly recognized contributor to chronic kidney disease and end‐stage renal disease. It can result from various underlying conditions, including monoclonal gammopathies and chronic inflammatory states. Diagnosis is typically established by kidney biopsy demonstrating characteristic amyloid deposits. ALECT2 (leukocyte chemotactic factor 2) amyloidosis can present as nephrotic‐range proteinuria. ALECT2 amyloidosis is an uncommon and under‐recognized.