# Poster Session II – Poster of Distinction II A319 UPREGULATION OF COLLAGEN 4 IS CORRELATED WITH INCREASED TISSUE STIFFNESS OF MOUSE EMBRYONIC MODEL OF HIRSCHSPRUNG DISEASE

**Authors:** D Lee, M Zhu, S Hopyan, B Li, A Pierro

PMC · DOI: 10.1093/jcag/gwaf042.318 · Journal of the Canadian Association of Gastroenterology · 2026-02-13

## TL;DR

The study explores the relationship between collagen 4 upregulation and tissue stiffness in a mouse model of Hirschsprung disease.

## Contribution

The novel contribution is identifying collagen 4 upregulation as correlated with increased tissue stiffness in an embryonic mouse model of Hirschsprung disease.

## Key findings

- Collagen 4 is upregulated in the mouse embryonic model of Hirschsprung disease.
- This upregulation correlates with increased tissue stiffness in the model.

## Abstract

NOT PUBLISHED AT AUTHOR’S REQUEST

Please acknowledge all funding agencies listed below

CAG, CIHRSickKids Restracomp, University of Toronto Yuet Ngor Wong

## Linked entities

- **Diseases:** Hirschsprung disease (MONDO:0007723)
- **Species:** Mus musculus (taxon 10090)

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Source: https://tomesphere.com/paper/PMC12900872