# Effect of polyethylene glycol loxenatide on weight loss in super-obese patients with type 2 diabetes: a randomized controlled trial

## TL;DR

A drug called PEG-Loxe helped super-obese type 2 diabetes patients lose weight and improve blood sugar control over 24 weeks.

## Contribution

This is the first randomized trial showing PEG-Loxe's effectiveness in weight loss and metabolic improvement in super-obese T2DM patients.

## Key findings

- PEG-Loxe significantly reduced weight compared to placebo in super-obese T2DM patients.
- The drug improved glycemic control and increased HDL levels during treatment.
- Adverse reactions were mainly gastrointestinal and more common in PEG-Loxe groups.

## Abstract

To investigate the efficacy and safety of polyethylene glycol loxenatide (PEG-Loxe) for weight reduction and metabolic improvement in super-obese patients with type 2 diabetes mellitus (T2DM).

This was a single-center, single-blind, randomized, controlled clinical trial. A total of 123 study participants were enrolled and randomly assigned to the PEG-Loxe low-dose group (300 μg/week), PEG-Loxe high-dose group (400 μg/week), and placebo group. In total, 105 participants completed the study. The primary endpoint was the difference in weight reduction between groups.

All three groups had similar baseline characteristics. The least squares mean, 95% confidence interval (LSM, 95% CI) change in weight from baseline to week 24 was greater in the PEG-Loxe 300 μg group -16.34 (-19.10, -13.58) kg and PEG-Loxe 400 μg group -21.14 (-23.90, -18.37) kg compared to the placebo group -6.75 (-9.51, -3.99) kg (P < 0.001). Glycated hemoglobin levels decreased from the baseline by 0.50%, 1.02%, and 1.34% in the placebo, low-dose, and high-dose groups, respectively. The PEG-Loxe treatment group showed a significant reduction in waist circumference and increased high-density lipoprotein levels during the study period. The rate of adverse drug reactions was higher in the PEG-Loxe 400 μg group (36.11%) and the PEG-Loxe 300 μg group (25.00%) than in the placebo group (11.43%). Adverse reactions were predominantly gastrointestinal.

For super-obese patients with T2DM, continuous treatment with PEG-Loxe for 24 weeks can effectively reduce body weight and achieve good glycemic control.

www.chictr.org.cn, identifier ChiCTR2100052922.