# Unveiling the multifaceted roles of extracellular vesicles in cancer: insights from molecular imaging and engineering strategies: EVs and cancer: advances in molecular imaging

## TL;DR

This paper reviews how extracellular vesicles (EVs) contribute to cancer progression and their potential use in cancer therapies and imaging.

## Contribution

The paper highlights recent advances in EV-based molecular imaging and engineering for cancer theranostics.

## Key findings

- EVs facilitate tumor progression and metastasis through intercellular communication.
- EVs can deliver noncoding RNAs that modulate immune cell function and exert antitumor effects.
- Engineered EVs show promise as both drug delivery systems and molecular imaging probes in cancer treatment.

## Abstract

Extracellular vesicles (EVs), a class of nanoscale, membrane-bound vesicles secreted by various cell types, have emerged as rapidly advancing fields of research in recent years. This heterogeneous vesicle is a versatile carrier system for a variety of biomolecules, including proteins, nucleic acids, and metabolites. EVs play pivotal roles in intercellular communication, immune regulation, and disease pathogenesis, with particular implications for cancer biology. On the one hand, EVs promote tumor progression and metastasis by facilitating communication between cancer cells and their microenvironment. On the other hand, EVs carry noncoding RNAs, such as miRNAs and other regulatory RNAs, which directly modulate immune cell function or exert antitumor effects by influencing cancer cell proliferation and apoptosis. In addition to their biological roles, EVs show great potential as drug delivery systems because of their ability to be effectively taken up by target cells and stably deliver therapeutic payloads. In the context of cancer therapy, natural EVs demonstrate inherent therapeutic potential, particularly in targeting highly metabolically active organs. Furthermore, engineered EVs, which serve as both therapeutic vehicles and molecular imaging probes, have demonstrated significant potential for cancer theranostics. This review focuses on elucidating the dynamic changes and biological functions of EVs
in vivo, with the aim of exploring the translational potential of EV-based molecular imaging and tracing technologies in cancer treatment. This work seeks to provide critical insights that may enhance the precision and efficacy of tumor therapies, offering a foundation for future clinical applications.