# Global, regional, and national trends in hypertensive heart disease burden due to high BMI: a 30-year analysis using GBD 2021 data with projections to 2035

**Authors:** Muhammad Babar Khawar, Kaleem Maqsood, Rui Sang, Javeria Malik, Ali Afzal, Azeem Saeed, Farwa Liaqat, Humera Naveed, Akasha Fiaz, Chatchai Muanprasat, Jing Zhou

PMC · DOI: 10.3389/fpubh.2026.1701954 · Frontiers in Public Health · 2026-01-30

## TL;DR

This study uses global data to show how high BMI contributes to heart disease and predicts future trends up to 2035.

## Contribution

The paper provides a 30-year analysis and future projections of high BMI-related heart disease using GBD 2021 data.

## Key findings

- Global DALYs due to high BMI-related heart disease increased from 5.67 million to 12.55 million between 1990 and 2021.
- Men experienced an 8.28% increase in DALYs, while women's burden remained stable.
- Projections suggest a gradual decrease in the burden by 2035, but high BMI-related heart disease remains a public health concern.

## Abstract

High body mass index (BMI)-related hypertensive heart disease (HHD) is increasingly prevalent worldwide. Using Global Burden of Disease (GBD) 2021 data, we analyzed the changes in disability-adjusted life years (DALYs) and age-standardized rate (ASR) of mortality (ASMR) due to high BMI from 1990 to 2021.

HHD data on high BMI were obtained from GBD 2021 at global, regional, and country levels. Age-standardized DALYs (ASDR) and deaths (ASMR) were calculated, with trends analyzed based on gender, age, and region. The autoregressive integrated moving average (ARIMA) model was used to project the burden through 2035, while the estimated annual percentage change (EAPC) was used to assess future trends.

From 1990 to 2021, global DALYs increased from 5.67 million to 12.55 million (a 1.81% rise in ASR), and deaths rose from 240,000 to 594,000. Men showed an 8.28% increase in DALYs, while women’s burden remained stable with a slight ASR decline. The highest burden was observed in those aged 80 and older, with DALYs increasing from 1243.80 to 1604.32. Projections suggest gradual decreases in DALYs and ASMR by 2035, although high BMI-related HHD remains a major public health concern.

High BMI intensifies HHD prevalence, particularly among men and older adults. Despite projected minor decreases by 2035, rising obesity underscores the ongoing need for public health interventions.

## Linked entities

- **Diseases:** hypertensive heart disease (MONDO:0001302)

## Full-text entities

- **Diseases:** obesity (MESH:D009765), deaths (MESH:D003643), HHD (MESH:D006973)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Full text

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## Figures

5 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12900672/full.md

## References

47 references — full list in the complete paper: https://tomesphere.com/paper/PMC12900672/full.md

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Source: https://tomesphere.com/paper/PMC12900672