# Processing-Dependent Releasing of Iron from Plant Ferritin in Cereal-Based Foods Designed for Iron Delivery in Inflammatory Bowel Disease

**Authors:** Magdalena Zielińska-Dawidziak, Agnieszka Makowska, Magdalena Czlapka-Matyasik, Aleksandra Proch, Przemysław Niedzielski

PMC · DOI: 10.3390/molecules31030510 · Molecules · 2026-02-02

## TL;DR

This study examines how iron from plant ferritin in fortified soybean sprouts is released during food processing in products designed to treat anemia in inflammatory bowel disease.

## Contribution

The study identifies processing effects on ferritin-iron release and speciation in cereal-based products for iron delivery.

## Key findings

- Crispbread processing disrupted ferritin and released ferritin-iron, with ~30% remaining as Fe(III).
- Rice wafers with coarse sprout fractions lost ~3% of ferritin-iron, mostly converting it to ferrous iron.
- Designed products retain high plant ferritin iron content despite processing losses.

## Abstract

Fortified soybean sprouts have been proposed as a source of ferritin-iron in food for the treatment of anemia in inflammatory bowel disease. Eight products with the addition of the sprouts have been designed, and iron speciation was studied in them by flame atomic absorption spectrometry (total iron content) and spectrophotometry (ionic forms). Non-ionic iron content, considered ferritin-iron content, was calculated as the difference between total and inorganic iron content. The production of crispbread disrupted ferritin and caused the release of ferritin-iron. A loss of ~3% of ferritin-iron was noted in rice wafers containing a coarse fraction of sprouts, and 0–10% in instant products (‘kisiel’, ‘budyn’, and groats). Lost ferritin-iron was converted mostly into ferrous iron, except for crispbread, in which Fe(III) constituted ~30%. The designed products are valuable sources of iron, with a high content of plant ferritin.

## Linked entities

- **Chemicals:** ferrous iron (PubChem CID 23925), Fe(III) (PubChem CID 29936)
- **Diseases:** inflammatory bowel disease (MONDO:0005265), anemia (MONDO:0002280)

## Full-text entities

- **Diseases:** Inflammatory Bowel Disease (MESH:D015212), anemia (MESH:D000740)
- **Chemicals:** Fe(III) (-), Iron (MESH:D007501)
- **Species:** Oryza sativa (Asian cultivated rice, species) [taxon 4530], Glycine max (soybean, species) [taxon 3847]

## Full text

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## References

36 references — full list in the complete paper: https://tomesphere.com/paper/PMC12899946/full.md

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Source: https://tomesphere.com/paper/PMC12899946