# Design and Synthesis of Planar Chiral Bisphosphine Ligands Based on Diphenyl [2.2]-Paracyclophane

## TL;DR

Researchers developed a new type of chiral ligand that can be used in catalytic reactions to produce specific chemical structures efficiently.

## Contribution

A practical synthesis method for a new family of planar chiral bisphosphine ligands based on diphenyl [2.2]-paracyclophane is introduced.

## Key findings

- PhPhanePHOS ligands were synthesized in four steps from 4,12-bisbromo-[2.2]paracyclophane.
- The ligands showed high catalytic activity in Pd-catalyzed asymmetric allylic alkylation reactions.

## Abstract

Planar chiral bisphosphine ligands based on diphenyl [2.2]paracyclophane (PhPhanePHOS) were successfully synthesized in a practical manner in four steps from commercially available 4,12-bisbromo-[2.2]paracyclophane as a new family of bisphosphine ligands. The novel PhPhanePHOS ligands provide high catalytic activity in Pd-catalyzed asymmetric allylic alkylation reactions in preliminary experiments.