# Gut Microbiota Impact on Cognitive Function in Humans

**Authors:** Soghra Bagheri, Ireneusz Ryszkiel, Agata Stanek

PMC · DOI: 10.3390/nu18030369 · Nutrients · 2026-01-23

## TL;DR

This study explores how gut bacteria may influence human cognitive function, based on recent human research.

## Contribution

The paper synthesizes recent human studies to clarify the gut microbiota's role in cognitive function.

## Key findings

- Gut microbiota is linked to cognitive function in both healthy and diseased states.
- Some studies suggest a potential causal relationship between gut microbiota and cognitive changes.
- Findings indicate both direct and inverse relationships between microbiota composition and cognition.

## Abstract

The human gut microbiome and its relationship with both physiological and pathological functions have long intrigued researchers. One of the most fascinating and important areas within this domain is cognitive function. Given that a substantial number of studies, especially interventional ones, have been conducted on animal models, the findings of which are not fully generalizable to humans and may therefore be misinterpreted, the purpose of this study is to synthesize evidence from the most recent human research. Current evidence indicates that the gut microbiota is linked to cognitive function in both healthy and diseased states, with numerous studies suggesting a potential causal relationship between the two. Although the majority of these studies associate changes in cognitive function with differences in the composition of the gut microbiota, some findings also indicate an inverse relationship.

## Full-text entities

- **Species:** Homo sapiens (human, species) [taxon 9606], gut metagenome (species) [taxon 749906]

## Full text

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## Figures

2 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12899800/full.md

## References

83 references — full list in the complete paper: https://tomesphere.com/paper/PMC12899800/full.md

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Source: https://tomesphere.com/paper/PMC12899800