# Omega Nucleic Acids (ΩNA), Ultimate Nucleic Acids for Future Technology

**Authors:** Shogo Hamada, Keiji Murayama, Yusuke Takezawa, Ryojun Toyoda, Akinori Kuzuya

PMC · DOI: 10.3390/molecules31030523 · Molecules · 2026-02-02

## TL;DR

This paper proposes Omega Nucleic Acids (ΩNA), a new concept for artificial nucleic acids designed to overcome the limitations of DNA and RNA in advanced technologies.

## Contribution

The paper introduces the novel concept of ΩNA as a thought experiment for future nucleic acid-based technologies.

## Key findings

- Natural nucleic acids have limitations that hinder their use in advanced molecular technologies.
- ΩNA is proposed as a next-generation nucleic acid with customizable properties for extreme environments.
- The paper outlines specifications and potential functions for building an ΩNA-based ecosystem.

## Abstract

DNA and RNA, by focusing on their unique molecular properties, have transcended their role as carriers of genetic information in life and pioneered new application fields such as molecular robotics and molecular computing. However, as these technologies advance, the limitations inherent in natural nucleic acids and their ecosystems are increasingly becoming apparent as barriers to further application. To overcome these constraints, efforts to create artificial nucleic acids using chemical synthesis are underway and are now reaching a new stage of development. This paper proposes a concept of ultimate nucleic acid, “Omega Nucleic Acids (ΩNA),” as a thought experiment. We discuss the specifications required for this molecule, its implementable functions and approaches, and the construction of an ecosystem centered around ΩNA. By working backward from the characteristics of known natural and artificial nucleic acids, while envisioning next-generation artificial systems and applications in extreme environments, we aim to explore new approaches to nucleic acid chemistry and provide guidelines for constructing innovative artificial molecular systems.

## Full-text entities

- **Chemicals:** Omega Nucleic Acids (-)

## Full text

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## Figures

4 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12899278/full.md

## References

361 references — full list in the complete paper: https://tomesphere.com/paper/PMC12899278/full.md

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Source: https://tomesphere.com/paper/PMC12899278