# Neuroprotective Herbs Associated with Parkinson’s and Alzheimer’s Disease

## TL;DR

This paper reviews how natural plant compounds might help treat or prevent Parkinson’s and Alzheimer’s diseases by acting as antioxidants.

## Contribution

The paper provides a comprehensive review of phytochemical-based strategies for Parkinson’s and Alzheimer’s disease treatment and prevention.

## Key findings

- Phenolic compounds like polyphenols and flavonoids show antioxidant potential relevant to neurodegenerative diseases.
- In vivo and in vitro studies suggest herb-derived components could be effective in managing Parkinson’s and Alzheimer’s.
- The paper identifies recent herb-derived candidates for future drug development in PD/AD.

## Abstract

There is currently no treatment for Parkinson’s (PD) and Alzheimer’s (AD) diseases, and medications that target the blockage of amyloid plaque cascades appear to be the most promising for preventing these diseases. However, it is believed that consuming natural antioxidants, particularly phytochemicals such as phenolic compounds, may help the treatment process for neurodegenerative illnesses. Phenolic substances such as phenolic acids, polyphenols, and flavonoids have been shown to have antioxidant properties in plants and are thought to have a similar impact in humans. This review provides an analysis of the current landscape of PD and AD pathophysiology, paying particular attention to phytochemical-based therapeutic, preventive, and management strategies using disclosed herb candidates in in vivo/vitro studies. We also highlight the herb-derived components that have recently been identified for their effects in the treatment of PD/AD to provide a review and perspectives for the development of the next generation of drugs and preparations for the treatment of PD/AD.