# Association Between Depression and Polypharmacy in Older Adults—A Systematic Review and Meta‐Analysis

## TL;DR

Depression in older adults is strongly linked to polypharmacy, suggesting the need for better mental health and medication management.

## Contribution

This study provides a meta-analysis showing a significant association between depression and polypharmacy in older adults.

## Key findings

- Depression is associated with polypharmacy in older adults (OR = 2.49; 95% CI: 1.88–3.29).
- The association is consistent across community-based and institutional/clinic-based populations.
- Six of the eight included studies were rated as high quality.

## Abstract

Depression and polypharmacy are both common among older adults and may be closely interrelated.

This systematic review and meta‐analysis examined the association between depression and polypharmacy by searching EMBASE, PubMed, Web of Science, and PsycINFO from inception to 18 May 2023. The review was registered in PROSPERO (CRD42022343619).

Eight studies met the inclusion criteria, with six rated high quality and two medium quality. Pooled analysis using a random‐effects model demonstrated a strong association between depression and polypharmacy (OR = 2.49; 95% CI: 1.88–3.29; I² = 83%). Subgroup analyses revealed consistently elevated associations in both community‐based and institutional/clinic‐based populations.

Depression is associated with polypharmacy among older adults. These findings underscore the importance of integrating mental health assessment into medication management strategies for older adults.