# Latent profile analysis of self-neglect and associated factors among rural older adults with chronic diseases: a cross-sectional study

**Authors:** Zihan Yi, Chengchuan Chen, Zikejimu Sun, Chaoxiang You, Mei Ju, Na Zhou

PMC · DOI: 10.3389/fpubh.2026.1738418 · Frontiers in Public Health · 2026-01-28

## TL;DR

This study identifies different levels of self-neglect among older adults in rural China with chronic diseases and suggests targeted interventions for each level.

## Contribution

The study introduces a novel application of latent profile analysis to identify distinct self-neglect profiles and their associated factors in rural older adults with chronic diseases.

## Key findings

- Four distinct self-neglect profiles were identified: low-level, selective mild, moderate, and severe neglect.
- Each profile is associated with unique risk factors such as economic status, social support, and depression.
- Interventions should be tailored to each profile, focusing on economic support, health monitoring, and psychosocial engagement.

## Abstract

This study aimed to identify heterogeneous profiles of self-neglect (ESN) and their associated factors among rural Chinese older adults with chronic diseases.

A cross-sectional survey was conducted among 719 rural older adults with chronic diseases in Sichuan, China, from January to June 2020. The questionnaire included sociodemographic and health-related characteristics, as well as the Three-Item UCLA Loneliness Scale (UCLALS-3), the Social Support Rating Scale (SSRS), the Scale of Older Adults Self-Neglect (SESN), the Five-Item Geriatric Depression Scale (GDS-5), and the Short Portable Mental Status Questionnaire (SPMSQ). Latent profile analysis (LPA) was conducted to identify distinct patterns of patterns of self-neglect among older adults (ESN).

Four profiles were identified: low-level neglect (35.0%), selective mild neglect (37.7%), moderate neglect (14.7%), and severe neglect (12.5%). Compared with the low-level neglect group, selective mild neglect was more common among participants with poorer economic status, poor sleep quality, and alcohol consumption. The moderate neglect profile was associated with older age, lack of regular physical examinations, smoking, pain, cognitive impairment, and lower social support. Severe neglect was marked by the absence of grandchild caregiving, higher loneliness, smoking, and depression. Pairwise comparisons indicated stage-dependent patterns, with reversed associations for social support (protective in moderate neglect but a risk marker in severe neglect) and pain (a risk factor in moderate neglect, whereas its absence indicated higher risk in severe neglect).

ESN among older adults with chronic diseases in rural China is heterogeneous and comprises distinct latent profiles with stage-dependent risk factors. For selective mild neglect, interventions should emphasize economic and lifestyle support. For moderate neglect, priorities include routine monitoring, regular physical examinations, and health literacy promotion. For severe neglect, intensive psychosocial interventions should address depression and loneliness and promote alternative engagement in family roles, particularly among older adults who do not provide grandchild caregiving. Integrating these profile-specific strategies into rural primary care may help reduce self-neglect and improve health outcomes in this vulnerable population.

## Full-text entities

- **Diseases:** impaired emotional regulation (MESH:C565631), hypertension (MESH:D006973), COVID-19 (MESH:D000086382), fire (MESH:D000092422), psychological (MESH:D000067073), Chronic pain (MESH:D059350), Depression (MESH:D003866), Chronic sleep deprivation (MESH:D012892), executive dysfunction (MESH:D006331), diabetic peripheral neuropathy (MESH:D010523), chronic disease (MESH:D002908), communication disorders (MESH:D003147), neuropathy (MESH:D009422), Cognitive impairment (MESH:D003072), prefrontal (MESH:C536329), inflammatory (MESH:D007249), disease (MESH:D004194), APS (MESH:C538052), coronary heart disease (MESH:D003327), sleep problems (MESH:D012893), anhedonia (MESH:D059445), Pain (MESH:D010146), cancer (MESH:D009369), diabetes (MESH:D003920), sensory impairment (MESH:D012678), functional decline (MESH:D060825), neuroinflammation (MESH:D000090862), self (MESH:D012652), stroke (MESH:D020521), COPD (MESH:D029424), fatigue (MESH:D005221), Self-Neglect (MESH:D058069), Self-Care Deficit (MESH:D009461), frailty (MESH:D000073496)
- **Chemicals:** KY2019274 (-), Alcohol (MESH:D000438), cortisol (MESH:D006854)
- **Species:** Homo sapiens (human, species) [taxon 9606], Nicotiana tabacum (American tobacco, species) [taxon 4097]

## Full text

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## References

62 references — full list in the complete paper: https://tomesphere.com/paper/PMC12897509/full.md

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Source: https://tomesphere.com/paper/PMC12897509