# Association of Peripheral Inflammatory Markers with Conception Outcomes Among Women with Endometriosis-Associated Infertility

## TL;DR

This study explores how pre-surgery blood markers of inflammation can predict natural pregnancy outcomes in women with endometriosis-related infertility.

## Contribution

The study identifies specific inflammatory biomarkers that correlate with spontaneous pregnancy after endometriosis surgery.

## Key findings

- The pregnancy group had significantly lower NLR, dNLR, PLR, SIRI, and SII values compared to the non-pregnancy group.
- SII, NLR, and dNLR showed the highest ability to predict spontaneous conception.
- Lower NLR and dNLR values were associated with higher odds of spontaneous pregnancy in regression analyses.

## Abstract

Background: Predicting natural conception following surgical treatment remains a clinical challenge for endometriosis, a chronic inflammatory condition often associated with infertility. This study aimed to determine if simple, low-cost inflammatory biomarkers, such as NLR, dNLR, LMR, PLR, SIRI, PIV, and SII calculated from routine preoperative blood tests are associated with spontaneous pregnancy in women with endometriosis-related infertility after laparoscopic surgery. Methods: A retrospective analysis was conducted on 78 women between the ages of 18 and 48 who underwent standardized laparoscopic surgery and were monitored for up to 18 months. Results: The pregnancy group had significantly lower NLR, dNLR, PLR, SIRI, and especially SII values than the non-pregnancy group. Among the evaluated markers, SII, NLR, and dNLR demonstrated the highest discriminative ability for spontaneous conception. In regression analyses, lower values of NLR and dNLR were associated with higher odds of spontaneous pregnancy. Conclusions: These findings suggest a correlation between preoperative inflammatory status and postoperative reproductive outcomes in women with endometriosis.