# Inner Ear Anatomy Variations in Acute Low-Tone Sensorineural Hearing Loss and Unilateral Stage I/II Ménière’s Disease: A Comparative Study

## TL;DR

This study compares inner ear anatomy in patients with acute low-tone hearing loss and early-stage Ménière’s disease using MRI, finding anatomical differences that may help distinguish these conditions.

## Contribution

The study identifies distinct inner ear anatomical variations in Ménière’s disease but not in acute low-tone hearing loss, offering new insights into their pathogenesis.

## Key findings

- Ménière’s disease patients showed shorter posterior fossa distances in unaffected ears compared to healthy controls.
- Acute low-tone hearing loss patients had higher vestibular aqueduct visibility in affected ears compared to Ménière’s disease patients.
- A significant negative correlation was found between posterior fossa distance and hearing loss severity in Ménière’s disease patients.

## Abstract

Objectives: To investigate the differences in inner ear anatomical variations between patients with acute low-tone sensorineural hearing loss (ALHL) and those with unilateral stage I/II Ménière’s disease (MD) based on magnetic resonance imaging (MRI). Methods: A total of 30 patients with unilateral ALHL, 41 patients with unilateral stage I/II MD, and 59 healthy controls were enrolled retrospectively. 3.0T MRI was used to evaluate the distance between the vertical part of the posterior semicircular canal and the posterior fossa (PPD) and vestibular aqueduct (VA) visibility. Inter-group and intra-group comparisons and correlation analyses were performed to clarify the characteristics of anatomical variations. Results: (1) There were no significant differences in PPD and VA visibility between ALHL patients and healthy controls; the PPD of unaffected ears in MD patients was significantly shorter than that in healthy controls, while no significant difference was observed in the PPD of affected ears between MD patients and healthy controls. (2) The VA visibility of affected ears in ALHL patients was significantly higher than that in MD patients. (3) No significant intra-group differences in PPD and VA visibility between affected and unaffected ears were noted in ALHL or MD patients. (4) A significant negative correlation was found between the PPD of affected ears and pure tone average of affected ears in MD patients, while no correlations were observed between anatomical indices and clinical characteristics in ALHL patients. Conclusions: Although both ALHL and MD are categorized as hydropic ear diseases, radiological evidences demonstrate that MD patients exhibit inner ear anatomical variations, whereas no significant anatomical variations are observed in ALHL patients. This suggests that anatomical variations in the endolymphatic drainage system may be a predisposing factor for the pathogenesis of unilateral MD rather than for unilateral ALHL.