Immune-Centered Cross-Talk Between Cancer Cells and the Tumor Microenvironment—Implications for Therapy
Eliza Turlej, Aleksandra Domaradzka, Rostyslav Koksharov, Agnieszka Gizak
TL;DR
This review discusses how cancer interacts with its surrounding environment and how targeting this interaction can improve cancer treatments.
Contribution
The paper provides new insights into how therapies can be improved by modifying immune cells in the tumor microenvironment.
Findings
Modified immune cells like engineered macrophages can enhance cancer recognition and destruction.
The tumor microenvironment significantly influences cancer cell proliferation and treatment response.
Various therapies targeting the tumor microenvironment are effective across different solid tumors.
Abstract
Cancer develops in a complex environment composed of many different cells that can either support or hinder treatment. Modern therapies, including immune-based approaches, increasingly target not only the cancer cells themselves but also the surrounding cells that support tumor growth. In this review, we describe how different treatment methods influence the tumor environment and how this knowledge can lead to more effective and personalized therapies. We also present new strategies that use modified immune cells, such as engineered macrophages, to improve the body’s ability to recognize and destroy cancer. Understanding how therapies interact with the tumor environment can help scientists design better therapies and improve outcomes for patients in the future. The tumor microenvironment (TME), composed of various immune and non-immune cells, as well as cancer stem cells, plays a…
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Taxonomy
TopicsCancer Research and Treatments · Cancer Cells and Metastasis · Nanoplatforms for cancer theranostics