# Correction: Choline alphoscerate: insights between acquired certainties and future perspectives

**Authors:** Giovanni Biggio, Claudio Mencacci

PMC · DOI: 10.3389/fnagi.2026.1744201 · 2026-01-29

## TL;DR

This paper explores how choline alphoscerate affects brain function, focusing on cognitive enhancement and its potential in Alzheimer's and aging.

## Contribution

The paper provides new insights into the mechanisms of choline alphoscerate's effects on cognitive functions and synaptic signaling.

## Key findings

- Choline alphoscerate enhances cognitive functions and synaptic signaling.
- It influences acetylcholine neurotransmission and membrane lipid composition.
- The compound shows potential in modulating gene expression and cholinergic tone.

## Abstract

Diagram illustrating the effects of choline alphoscerate on the brain. It highlights benefits like enhancement of cognitive functions and synaptic signaling. Key aspects include epigenetic regulation, acetylcholine neurotransmission, and membrane lipid composition. The diagram shows interactions with enzymes and neurotransmitters in the synaptic cleft, and includes references to Alzheimer's disease and healthy aging. Various compounds and neurotransmitters like acetylcholine, SAM, and Co-A are labeled, with processes such as the modulation of gene expression and enhancement of cholinergic tone noted. The image includes a legend for anti-cholinesterases.

## Linked entities

- **Chemicals:** choline alphoscerate (PubChem CID 657272), acetylcholine (PubChem CID 187), SAM (PubChem CID 34755), Co-A (PubChem CID 87642)
- **Diseases:** Alzheimer's disease (MONDO:0004975)

## Full-text entities

- **Chemicals:** Choline (MESH:D002794)

## Figures

1 figure with captions in the complete paper: https://tomesphere.com/paper/PMC12895435/full.md

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Source: https://tomesphere.com/paper/PMC12895435