# Mosquito‐Borne Viruses of Clinical Significance

## TL;DR

This review summarizes the global impact of mosquito-borne viruses, highlighting their spread, health risks, and the need for better diagnostics and vaccines.

## Contribution

The paper provides a comprehensive synthesis of current knowledge and research gaps on mosquito-borne viruses.

## Key findings

- Mosquito-borne viruses are expanding geographically due to climate change and urbanization.
- Current diagnostic methods have limitations in sensitivity and specificity.
- There is a lack of effective vaccines and limited antiviral treatment options.

## Abstract

Mosquito‐borne viruses represent a significant public health concern globally, with rising incidence rates leading to increased morbidity and mortality. This review aims to synthesize current knowledge regarding mosquito‐borne viruses, focusing on their geographic distribution, clinical impact, diagnostic challenges, treatment options, and existing research gaps.

A comprehensive literature search was conducted across multiple electronic databases, including PubMed, Web of Science, Scopus, Google Scholar, and the Cochrane Library. Studies published from January 2000 to the present were included, focusing on peer‐reviewed articles related to mosquito‐borne viruses. Data extraction and synthesis followed a structured methodology, assessing both the quality of included studies and the themes relevant to mosquito‐borne viruses.

The review revealed significant geographic expansion of mosquito‐borne viruses, facilitated by climate change and urbanization, affecting regions previously considered low risk. Clinical manifestations varied widely, with vulnerable populations, such as children and the elderly, being at higher risk for severe outcomes. Diagnostic methods, while improving, faced limitations in sensitivity and specificity. Treatment primarily focused on symptomatic relief, with limited antiviral options currently available. Notable gaps in research were identified, particularly in the development of effective vaccines and rapid diagnostic tools.

The findings underscore the urgent need for integrated public health strategies to combat mosquito‐borne viruses. Enhancing surveillance systems, improving diagnostic capabilities, expanding treatment options, and fostering vaccine development are critical steps. Addressing the identified research gaps will help mitigate the impacts of mosquito‐borne viruses on global health.