# Successful Management of Meningitis and Sepsis Due to Multidrug-Resistant Elizabethkingia meningoseptica in an Infant

## TL;DR

A premature infant with a severe multidrug-resistant infection made a full recovery using a specific antibiotic combination.

## Contribution

Demonstrates successful treatment of a rare and resistant infection with an unconventional antibiotic regimen.

## Key findings

- The infant fully recovered from multidrug-resistant Elizabethkingia meningoseptica infection.
- A combination of levofloxacin, ampicillin, and cefotaxime was effective despite resistance patterns.
- The case highlights the potential efficacy of non-standard antibiotic regimens in resistant infections.

## Abstract

We report a case of a two-month-old male infant, born prematurely, who initially presented with fever, irritability, and elevated inflammatory markers. He was then diagnosed with Elizabethkingia meningoseptica meningitis and sepsis. Treatment included intravenous levofloxacin, ampicillin, and cefotaxime. Despite the bacterium’s multidrug resistance and high reported morbidity and mortality rates, the patient made a full recovery with no complications at discharge or follow-up. This case demonstrates the challenges in treating E. meningoseptica infections and highlights the potential clinical efficacy of antibiotic regimens that may not align with standard susceptibility testing.