# Mazabraud Syndrome: The Contribution of Interventional Physiatry in a Clinical Case With 10 Years of Evolution

**Authors:** Alexandra Lagarto, Sandra Assunção, Sara Ribeiro Silva, Rodrigo Correia, José Luís Carvalho, Daniela Costa Martins

PMC · DOI: 10.7759/cureus.101376 · Cureus · 2026-01-12

## TL;DR

A 66-year-old woman with Mazabraud syndrome achieved pain relief through a minimally invasive interventional procedure after years of conservative treatment.

## Contribution

The paper introduces a novel, targeted interventional approach for symptom control in Mazabraud syndrome.

## Key findings

- The patient experienced complete pain relief after fluoroscopy-guided radiofrequency neurotomy.
- Functional recovery was sustained for five months post-intervention.
- The case highlights the diagnostic challenges of Mazabraud syndrome.

## Abstract

Mazabraud syndrome is a rare condition characterized by fibrous dysplasia and intramuscular myxomas. We present the case of a 66-year-old woman with chronic lumbosacral pain and imaging findings consistent with this syndrome, confirmed by biopsy. After years of conservative management with stable lesions but persistent symptoms, she underwent fluoroscopy-guided radiofrequency neurotomy of sacroiliac innervation, achieving complete pain relief and functional recovery. The patient was followed for five months after the intervention, with sustained symptom control and functional improvement. This case illustrates the diagnostic challenge and underscores the novelty of a targeted, minimally invasive interventional approach for symptom control in Mazabraud syndrome.

## Linked entities

- **Diseases:** Mazabraud syndrome (MONDO:0018933), fibrous dysplasia (MONDO:0000845)

## Full-text entities

- **Diseases:** lumbosacral pain (MESH:D010146), Mazabraud Syndrome (MESH:D013577), fibrous dysplasia (MESH:D005357), intramuscular myxomas (MESH:D009232)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Full text

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## Figures

3 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12893394/full.md

## References

13 references — full list in the complete paper: https://tomesphere.com/paper/PMC12893394/full.md

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Source: https://tomesphere.com/paper/PMC12893394