# Acute Acalculous Cholecystitis Secondary to Acute Pyelonephritis in a Young Woman: A Diagnostic Pitfall in the Emergency Department

**Authors:** Michal Balenkowski, Mateusz Antonow, Agnieszka Gorska, Mariusz Sieminski, Katarzyna Golabek

PMC · DOI: 10.7759/cureus.101362 · Cureus · 2026-01-12

## TL;DR

A young woman's gallbladder inflammation was actually caused by a kidney infection, showing the importance of advanced imaging in emergency diagnosis.

## Contribution

Highlights a rare diagnostic challenge where pyelonephritis mimics acalculous cholecystitis.

## Key findings

- Initial ultrasound suggested AAC, but CT revealed pyelonephritis with reactive gallbladder changes.
- Conservative antibiotic treatment led to full recovery without surgery.
- Emphasizes the need for advanced imaging to avoid unnecessary procedures.

## Abstract

Acute acalculous cholecystitis (AAC) is typically observed in critically ill patients, making its diagnosis in otherwise healthy individuals a significant clinical challenge. We present a rare case of a 29-year-old woman initially suspected of having AAC based on clinical assessment and ultrasonography. While initial imaging fulfilled the sonographic criteria for acalculous cholecystitis, subsequent contrast-enhanced computed tomography revealed right-sided acute pyelonephritis with secondary reactive gallbladder changes. The patient was successfully managed conservatively with intravenous followed by oral antibiotics, resulting in complete recovery without surgical intervention. This case underscores the potential for renal pathology to mimic primary biliary disease and highlights the critical role of advanced imaging in preventing unnecessary invasive procedures in the emergency department.

## Linked entities

- **Diseases:** acute acalculous cholecystitis (MONDO:0006633), acute pyelonephritis (MONDO:0003529)

## Full-text entities

- **Diseases:** Acalculous Cholecystitis (MESH:D042101), primary biliary disease (MESH:D008105), renal pathology (MESH:D002114), AAC (MESH:D041881), Acute Pyelonephritis (MESH:D011704)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Full text

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## Figures

2 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12893232/full.md

## References

11 references — full list in the complete paper: https://tomesphere.com/paper/PMC12893232/full.md

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Source: https://tomesphere.com/paper/PMC12893232