This paper is marked retracted in the scholarly record (OpenAlex). Interpret its findings with caution.
RETRACTION: Involvement of Heme Oxygenase‐1 Induction in the Cytoprotective and Immunomodulatory Activities of Viola patrinii in Murine Hippocampal and Microglia Cells
Evidence-Based Complementary and Alternative Medicine

Abstract
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TopicsBiochemical and Structural Characterization · Nicotinic Acetylcholine Receptors Study · Neuroinflammation and Neurodegeneration Mechanisms
RETRACTION: B. Li, D‐S. Lee, H‐G. Choi, K‐S. Kim, G‐S. Jeong, R. B. An, and Y‐C. Kim, “Involvement of Heme Oxygenase‐1 Induction in the Cytoprotective and Immunomodulatory Activities of Viola patrinii in Murine Hippocampal and Microglia Cells,” Evidence-Based Complementary and Alternative Medicine, vol. 2012 (2012). https://doi.org/10.1155/2012/128019.
The above article, published online on 24 March 2012 in Wiley Online Library (https://wileyonlinelibrary.com), has been retracted by John Wiley & Sons Ltd.
The retraction has been agreed following an investigation undertaken by the publisher, which identified multiple instances of inappropriately overlapping figures as follows:
- -In Figure 3a, the Western blot bands corresponding to actin expression share an unexpected similarity with the actin bands in Figure 5b of [1], which were obtained under different experimental conditions.
- -In Figure 5c, the Western blot bands corresponding to actin expression appear similar to the p‐38 bands in Figure 9a of [2].
- -Both sets of the Western Blot bands in Figure 6a share similarity with the bands in Figure 3c of [1]. Although the bands denote the expression of the same proteins, the experimental conditions are different.
- -Multiple bands from Figure 9b share unexpected similarities with Western Blot results in multiple publications by the author group, where they are used to represent different markers [1, 3, 4].
As a result of our investigation, the conclusions of the article can no longer be considered reliable, and it is therefore retracted.
The authors disagree with this retraction.
The reference list from the paper itself. Each links out to its DOI / PubMed record.
- 1Li B. , Lee D.-S. , Kang Y. , Yao N.-Q. , An R.-B. , and Kim Y.-C. , Protective effect of ganodermanondiol isolated from the Lingzhi mushroom against tert-butyl hydroperoxideinduced hepatotoxicity through Nrf 2-mediated antioxidant enzymes, Food and Chemical Toxicology. (2013) 53, 317–324, 10.1016/j.fct.2012.12.016, 2-s 2.0-84872372918.23266269 · doi ↗ · pubmed ↗
- 2Jeong G.-S. , Lee D.-S. , Kim D.-C. et al., Neuroprotective and anti-inflammatory effects of mollugin via up-regulation of heme oxygenase-1 in mouse hippocampal and microglial cells, European Journal of Pharmacology. (2011) 654, no. 3, 226–234, 10.1016/j.ejphar.2010.12.027, 2-s 2.0-79951674708.21236252 · doi ↗ · pubmed ↗
- 3Lee D.-S. , Ko W. , Quang T. H. et al., Penicillinolide A: A New Anti-Inflammatory Metabolite from the Marine Fungus Penicillium sp. SF-5292, Marine Drugs. (2013) 11, no. 11, 4510–4526, 10.3390/md 11114510, 2-s 2.0-84889261973.24225730 PMC 3853742 · doi ↗ · pubmed ↗
- 4Dong L. , Dongzhi Z. , Jin Y. et al., Taraxacum officinale Wigg. Attenuates Inflammatory Responses in Murine Microglia through the Nrf 2/HO-1 and NF-κB Signaling Pathways, The American Journal of Chinese Medicine. (2020) 42, no. 2, 445–462, 10.1142/S 0192415 X 20500238.32138531 · doi ↗ · pubmed ↗
