# Pancreatic lymphangioma and concurrent intestinal lymphangiectasia in a dog

**Authors:** Taisuke Ishikawa, Tomohide Kuramoto, Tatsuro Hifumi, Chika Kozuma, Machiko Kozuma, Keishi Hirano, Erisa Moriwaki, Shota Sakanoue, Noriaki Miyoshi, Naoki Miura, Osamu Yamato, Masashi Takahashi

PMC · DOI: 10.1093/jvimsj/aalaf033 · Journal of Veterinary Internal Medicine · 2026-02-11

## TL;DR

A 2-year-old dog with intestinal and pancreatic lymphatic issues was diagnosed with pancreatic lymphangioma and intestinal lymphangiectasia.

## Contribution

This case report describes a rare concurrent occurrence of pancreatic lymphangioma and intestinal lymphangiectasia in a dog.

## Key findings

- The pancreatic cyst was lined by lymphatic vessels with no atypia, suggesting pancreatic lymphangioma.
- Histopathology of jejunal samples showed lipogranulomatous lymphangitis and lymphangiectasia.
- The dog remained asymptomatic for 1 year after treatment with prednisolone and a low-fat diet.

## Abstract

A 2-year-old Border Collie presented with watery diarrhea and weight loss. Laboratory testing disclosed hypoproteinemia and abdominal imaging identified striations suggestive of intestinal lymphangiectasia and a polycystic mass contiguous with the pancreas. Clinical signs were transiently ameliorated by using prednisolone at an anti-inflammatory dosage, but hypoproteinemia recurred accompanied by ascites within 1 month. Exploratory laparotomy identified pancreatic cysts and extensive inflammation of the duodenum and jejunum, and biopsy samples were taken for histopathology. The pancreatic cyst was lined by lymphatic vessels with no atypia and surrounding collagen fibers, highly suggestive of pancreatic lymphangioma. Histopathology of jejunal biopsy samples disclosed lipogranulomatous lymphangitis and lymphangiectasia. After the laparotomy, the dog was treated with prednisolone at a physiologic dosage and a low-fat diet, and remained asymptomatic for 1 year.

## Linked entities

- **Chemicals:** prednisolone (PubChem CID 5755)
- **Diseases:** lymphangioma (MONDO:0002013), lymphangiectasia (MONDO:0006840)
- **Species:** Canis lupus familiaris (taxon 9615)

## Full-text entities

- **Genes:** PNLIP (pancreatic lipase) [NCBI Gene 477830], LYVE-1 [NCBI Gene 611529], ALB (albumin) [NCBI Gene 403550] {aka CSA}, PNLIPRP1 (pancreatic lipase related protein 1) [NCBI Gene 404010] {aka PLRP1}, VWF (von Willebrand factor) [NCBI Gene 399544] {aka F8VWF}
- **Diseases:** thoracic duct obstruction (MESH:D002779), peritoneal effusion (MESH:D010538), Lymphangiomas (MESH:D008202), PLE (MESH:D011504), Gorham's disease (MESH:D010015), tachypnea (MESH:D059246), lipogranulomatous lymphangitis (MESH:D008205), bone lesions (MESH:D001847), weight loss (MESH:D015431), intestinal lymphangiectasia (MESH:D008201), ascites (MESH:D001201), hypoproteinemia (MESH:D007019), intestinal malabsorption (MESH:D008286), polycystic mass (MESH:D016891), developmental abnormalities of intestinal lymphatics (MESH:D007410), Cysts (MESH:D003560), decreased appetite (MESH:D001068), pancreatic cyst (MESH:D010181), Lymphatic malformations (MESH:D008209), malignancy (MESH:D009369), congenital anomalies of the lymphatic system (MESH:D044148), cystic (MESH:D018297), Pancreatic lymphangioma (MESH:D010195), pancreatic cystic lesion (MESH:D003550), hypoglobulinemia (MESH:C565765), liver abscesses (MESH:D008100), inflammation (MESH:D007249), neovascularization (MESH:D016510), proteinuria (MESH:D011507), vomiting (MESH:D014839), congenital lymphatic malformations (MESH:C567452), congenital lymphatic disorder (MESH:D008206), Diarrhea (MESH:D003967), hypoalbuminemia (MESH:D034141), hyperemia (MESH:D006940)
- **Chemicals:** prednisolone (MESH:D011239), H&amp;E (MESH:D006371), Berberine tannate (-), clopidogrel (MESH:D000077144), dietary fat (MESH:D004041), hematoxylin (MESH:D006416), alcohol (MESH:D000438), eosin (MESH:D004801), sevoflurane (MESH:D000077149), propofol (MESH:D015742), cholesterol (MESH:D002784), atropine (MESH:D001285), fentanyl (MESH:D005283)
- **Species:** Homo sapiens (human, species) [taxon 9606], Solanum tuberosum (potatoes, species) [taxon 4113], Canis lupus familiaris (dog, subspecies) [taxon 9615]

## Full text

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## Figures

4 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12893210/full.md

## References

19 references — full list in the complete paper: https://tomesphere.com/paper/PMC12893210/full.md

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Source: https://tomesphere.com/paper/PMC12893210