# Meeting Review on India EMBO lecture course on RNA-protein complexes: from molecular assembly to physiological functions and disease

**Authors:** Debleena Mukhopadhyay, Nasrin Banu Mohammad Faisal, Chloe Leray, Sania Sultana

PMC · DOI: 10.1242/bio.062148 · Biology Open · 2026-01-26

## TL;DR

This paper summarizes a scientific meeting on RNA-protein complexes and their roles in cellular functions and disease.

## Contribution

The paper provides a review of recent advances and discussions from an EMBO lecture course on RNA-protein interactions.

## Key findings

- The meeting emphasized recent advances in RNA-protein interactions and their roles in cellular functions.
- Dysregulated post-transcriptional processes were highlighted as contributors to various diseases.
- Workshops on omics and phase separation were part of the course's methodological focus.

## Abstract

The India EMBO lecture course ‘RNA-protein complexes: from molecular assembly to physiological functions and disease’ was held at The National Centre for Cell Science, Pune, India, from February 24 to 28, 2025. The major theme of the lecture series centred on the recent advances in RNA-protein interactions and their role in regulating complex assembly or condensation as well as cellular functions and plasticity. Additionally, the course highlighted the impact of dysregulated post-transcriptional processes in various diseases. Speakers from various biological disciplines presented their research on both the fundamental architecture of RNA and protein complexes and their contributions to higher-order cellular functions. The course also featured flash talks and poster presentations selected from abstract submissions, alongside special methodological workshops on omics and phase separation. This Meeting Review reflects on the event's key discussions, drawing attention to the overarching themes and main conclusions.

Summary: This Meeting Review highlights talks from some of the renowned labs working on RNA and RBPs who participated in the EMBO lecture course ‘RNA-protein complexes: from molecular assembly to physiological functions and disease’ and gives an insight into their current work.

## Full-text entities

- **Genes:** ELAVL1 (ELAV like RNA binding protein 1) [NCBI Gene 1994] {aka ELAV1, HUR, Hua, MelG}, SMAD4 (SMAD family member 4) [NCBI Gene 4089] {aka DPC4, JIP, MADH4, MYHRS}, Eif4e (eukaryotic translation initiation factor 4E) [NCBI Gene 13684] {aka EG668879, Eif4e-ps, If4e, eIF-4E}, STAU1 (staufen double-stranded RNA binding protein 1) [NCBI Gene 6780] {aka PPP1R150, STAU}, RBMS3 (RNA binding motif single stranded interacting protein 3) [NCBI Gene 27303], TDRD9 (tudor domain containing 9) [NCBI Gene 122402] {aka C14orf75, HIG-1, HLS, NET54, SPGF30, SPNE}, C9orf72 (C9orf72-SMCR8 complex subunit) [NCBI Gene 203228] {aka ALSFTD, DENND9, DENNL72, FTDALS, FTDALS1}, FMR1 (fragile X messenger ribonucleoprotein 1) [NCBI Gene 2332] {aka FMRP, FRAXA, POF, POF1}, LARP1 (La ribonucleoprotein 1, translational regulator) [NCBI Gene 23367] {aka LARP, Lar1, Lhp1}, APC (APC regulator of Wnt signaling pathway) [NCBI Gene 324] {aka BTPS2, DESMD, DP2, DP2.5, DP3, GS}, SLBP (stem-loop histone mRNA binding protein) [NCBI Gene 7884] {aka HBP}, CTC1 (CST telomere replication complex component 1) [NCBI Gene 80169] {aka AAF-132, AAF132, C17orf68, CRMCC, tmp494178}, ENO1 (enolase 1) [NCBI Gene 2023] {aka ENO1-IT1, ENO1L1, HEL-S-17, MPB1, NNE, PPH}, UPF1 (UPF1 RNA helicase and ATPase) [NCBI Gene 5976] {aka HUPF1, NORF1, RENT1, UTF, pNORF1, smg-2}, CDH1 (cadherin 1) [NCBI Gene 999] {aka Arc-1, BCDS1, CD324, CDHE, ECAD, LCAM}, BAP1 (BRCA1 associated deubiquitinase 1) [NCBI Gene 8314] {aka HUCEP-13, KURIS, TPDS1, UBM2, UCHL2, UVM2}, Eif2a (eukaryotic translation initiation factor 2A) [NCBI Gene 229317] {aka D030048D22, D3Ertd194e}, MTOR (mechanistic target of rapamycin kinase) [NCBI Gene 2475] {aka FRAP, FRAP1, FRAP2, RAFT1, RAPT1, SKS}, RBP4 (retinol binding protein 4) [NCBI Gene 5950] {aka MCOPCB10, RDCCAS}, SMCR8 (SMCR8-C9orf72 complex subunit) [NCBI Gene 140775] {aka DENND8A}, VHL (von Hippel-Lindau tumor suppressor) [NCBI Gene 7428] {aka HRCA1, RCA1, VHL1, pVHL}, KDM6B (lysine demethylase 6B) [NCBI Gene 23135] {aka JMJD3, NEDCFSA, NEDSST}, NUP62 (nucleoporin 62) [NCBI Gene 23636] {aka IBSN, SNDI, p62}, CTNNB1 (catenin beta 1) [NCBI Gene 1499] {aka CTNNB, EVR7, MRD19, NEDSDV, armadillo}, TSLIG2 (tRNA splicing ligase complex subunit 2) [NCBI Gene 79074] {aka C2orf49, asw}, osk (oskar) [NCBI Gene 41066] {aka CG10901, Dm-osk, Dmel\CG10901, Oskar, norka}
- **Diseases:** neurological disorders (MESH:D009461), ASD (MESH:D000067877), striatal dysfunction (MESH:C563783), neurodegenerative diseases (MESH:D019636), cancer (MESH:D009369), T lymphoblastic leukaemia (MESH:D015458), CMD (MESH:C536560), ALS (MESH:D008113), FTD (MESH:D057180), male-specific abnormalities (MESH:D005058)
- **Chemicals:** N6-methyladenosine (MESH:C010223), m6A (MESH:C005955), PMC (MESH:C008859)
- **Species:** Mus musculus (house mouse, species) [taxon 10090], Drosophila melanogaster (fruit fly, species) [taxon 7227], Homo sapiens (human, species) [taxon 9606]

## Full text

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## Figures

2 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12893040/full.md

## References

60 references — full list in the complete paper: https://tomesphere.com/paper/PMC12893040/full.md

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Source: https://tomesphere.com/paper/PMC12893040