# First person – Jacob Trend

## TL;DR

Jacob Trend discusses his research on bone porosity and its dependence on VEGF in male bone, published in Disease Models & Mechanisms.

## Contribution

The study reveals spatial heterogeneity in cortical bone porosity and its VEGF dependency in males.

## Key findings

- Cortical bone porosity varies spatially in male bone.
- VEGF plays a key role in regulating bone porosity.
- The findings contribute to understanding bone structure and potential therapeutic targets.

## Abstract

First Person is a series of interviews with the first authors of a selection of papers published in Disease Models & Mechanisms, helping researchers promote themselves alongside their papers. Jacob Trend is first author on ‘
Cortical bone porosity is spatially heterogeneous and VEGF dependent in male bone’, published in DMM. Jacob conducted the research described in this article while a PhD student in Professor Claire Clarkin's lab at University of Southampton, Southampton, UK. He is now a research fellow in the lab of Professor Gavin Foster at University of Southampton, investigating multimodal, multiscale imaging and workflow development.