Effect of Moringa oleifera Protein‐Coated Gold Nanoparticles as Naturally Derived Disruptors of Biofilms
Lakshmi Sudhir Menon, Narendranath Ghosh, Sumit Biswas
TL;DR
Researchers developed a natural method using Moringa protein-coated gold nanoparticles to disrupt harmful biofilms on implants.
Contribution
Moringa oleifera protein-coated gold nanoparticles were shown to effectively disrupt Staphylococcus aureus biofilms without cytotoxicity.
Findings
p62-coated AuNPs efficiently disintegrated mature S. aureus biofilms compared to the protein alone.
p62-AuNPs disrupted bacterial cell morphology and caused cell death without harming human myoblast cells.
The protein-nanoparticle conjugate was stable and non-toxic, making it suitable for implant applications.
Abstract
Microbes having affinity to metallic surfaces develop a highly structured and sessile colony known as biofilms which poses significant challenges to the domain of implant surgery. Biofilm‐mediated infections and the associated burden have prompted the search for multipronged approaches to tackle the problem. Gram‐positive pathogens, most notably Staphylococcus aureus, has been known to colonize human tracts and form biofilms on implants and prosthetic devices. Antibiotic tolerance, drug efflux, and recalcitrance to the host immune response have added to the existing predicament of the biofilm infections. The search for inexpensive but effective avenues for combating biofilms has led to the use of metal nanoparticles conjugated with plant‐derived proteins. In this study, a protein from Moringa oleifera leaf extract, p62, which has been previously identified to have antibiofilm…
Genes, proteins, chemicals, diseases, species, mutations and cell lines named across the full text — each resolved to its canonical identifier and authoritative record.
Click any figure to enlarge with its caption.
Figure 1
Figure 2
Figure 3
Figure 4
Figure 5
Figure 6
Figure 7
Figure 8
Figure 9
Figure 10
Figure 11
Figure 12
Figure 13
Figure 14
Figure 15
Figure 16
Figure 17
Figure 18
Figure 19
Figure 20
Figure 21
Figure 22
Figure 23
Figure 24
Figure 25
Figure 26
Figure 27
Figure 28
Figure 29
Figure 30
Figure 31
Figure 32
Figure 33
Figure 34
Figure 35
Figure 36
Figure 37
Figure 38
Figure 39
Figure 40Peer Reviews
No public reviews on file for this paper yet. If you reviewed it on a platform where reviews are public (OpenReview, ICLR, NeurIPS, ICML), you can paste yours below so the community can read it here.
Videos
No videos yet. Explain this paper in a talk, walkthrough, or lecture? Add one.
Taxonomy
TopicsMoringa oleifera research and applications · Nanoparticles: synthesis and applications · Bacterial biofilms and quorum sensing