The spectrum of breast in situ papillary carcinomas with invasion and invasive breast carcinomas with papillary features: an overview of histological subtypes and diagnostic challenges
Emad A Rakha, Puay Hoon Tan, Wendy A Raymond
TL;DR
This paper reviews different types of invasive breast cancers with papillary features, focusing on their classification, diagnosis, and clinical implications.
Contribution
The paper provides an updated overview of the histological subtypes and diagnostic challenges of invasive breast carcinomas with papillary features.
Findings
IBCP includes six distinct subtypes with varying architecture and invasive behavior.
Standardized diagnostic criteria are needed to improve classification and patient outcomes.
Recognizing these subtypes is clinically relevant for prognosis and treatment decisions.
Abstract
Invasive breast carcinomas with papillary features (IBCP) constitute a distinct and morphologically diverse group of breast cancers characterised by varying degrees of papillary architecture and invasive behaviour. IBCP encompass (1) papillary carcinoma in situ associated with invasion, (2) invasive solid papillary carcinoma (ISPC), (3) encapsulated papillary carcinoma (EPC)‐like invasive carcinoma, (4) Papillary DCIS‐like invasive carcinoma, (5) high‐grade carcinomas with EPC‐like or SPC‐like morphology, and (6) invasive papillary carcinoma not otherwise specified (IPC), including the tubulopapillary pattern. This review summarises the evolving classification, histopathological features, diagnostic criteria, differential diagnoses, clinical prognosis, and treatment implications of various subtypes of IBCP. Particular attention is given to the diagnostic challenges and clinical…
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Taxonomy
TopicsBreast Lesions and Carcinomas · Breast Cancer Treatment Studies · Breast Implant and Reconstruction