# Global research landscape and multisystem health mechanisms of luteolin: a comprehensive bibliometric and network pharmacology study

## TL;DR

This study maps luteolin research trends and mechanisms from 2000 to 2025, revealing its potential for health benefits and disease prevention through multiple biological pathways.

## Contribution

The study introduces a comprehensive bibliometric and network pharmacology analysis of luteolin's mechanisms and research trends.

## Key findings

- Luteolin research has shown sustained growth, especially after 2021, with a shift in focus to metabolic health and immune regulation.
- Network pharmacology identified 239 potential targets, including TP53 and TNF, enriched in key pathways like p53 and PI3K–Akt.
- Luteolin is associated with potential therapeutic effects in neurological, immune, and metabolic disorders, as well as multiple tumors.

## Abstract

This study employs bibliometric and network pharmacology methods to systematically analyze the development trends, knowledge structure, and potential biological mechanisms of luteolin research from 2000 to 2025, providing insights for its application in nutritional health and disease prevention.

Based on the Web of Science Core Collection (WoSCC), combined with Bibliometrix, VOSviewer, and citespace, we conducted analyses of publication characteristics, keywords, journals, and co-citation networks. Simultaneously, integrating TM-MC, string, and Cytoscape, we constructed a luteolin target-pathway-disease network and performed core target and KEGG enrichment analyses.

Luteolin research exhibits sustained growth, with a significant increase after 2021. Research focus has expanded from early antioxidant and anti-inflammatory mechanisms to metabolic health, immune regulation, tumor suppression, and multisystem protection. Network pharmacology identified 239 potential targets, with core targets including TP53, TNF, STAT3, and EGFR, significantly enriched in p53, PI3K–Akt, TNF, and IL-17 pathways. Disease association networks indicate luteolin’s potential to intervene in neurological, circulatory, metabolic, immune, digestive, respiratory disorders, and multiple tumors, exhibiting typical multi-target comprehensive regulatory characteristics.