# Is gastroesophageal reflux linked to inflammation-related gestational complications and poor obstetric history?

## TL;DR

The study suggests that gastroesophageal reflux may be linked to inflammation-related pregnancy complications and poor obstetric outcomes.

## Contribution

The study identifies a potential association between GER and placenta-related pregnancy complications.

## Key findings

- GER was present in 7.59% of women in the study.
- Chronic inflammatory and autoimmune diseases were significantly more frequent in women with GER.
- The MTHFR 677TT genotype was more common in women with GER.

## Abstract

This study investigated inflammation-related co-morbidities in women with gastroesophageal reflux (GER) and poor gestational outcomes.

A retrospective cohort of 17 women with GER and 207 without GER who were admitted to a pre-conceptional counseling program was analyzed. All patients were evaluated for the presence of risk factors associated with obstetric complications and poor gestational outcomes, including hereditary thrombophilia, methylenetetrahydrofolate reductase (MTHFR) polymorphisms, type 2 diabetes mellitus, chronic inflammatory diseases, and autoimmune disorders.

GER was present in 7.59% (17/224) of women, and 35.3% (6/17) of GER-positive cases had gastritis and/or chronic peptic ulcer disease. Chronic inflammatory and autoimmune diseases were significantly more frequent in women with GER (p = 0.001 and p = 0.002, respectively). There was also a statistically significant difference in the distribution of MTHFR 677CC, -CT, and -TT genotypes in terms of the presence of GER (p = 0.036). A higher frequency of the MTHFR 677TT genotype was observed in women with GER.

Presence of GER may be indicative of inflammation-associated “placenta-related obstetric complications” and poor gestational outcomes in subsequent pregnancies.