# A Rare Case of Primary Nasal Tuberculosis

**Authors:** Khushboo G Malhotra, Ajeet K Khilnani, Ayush Tank, Aabha Parmar, Preet Hingrajiya

PMC · DOI: 10.7759/cureus.101214 · Cureus · 2026-01-10

## TL;DR

A rare case of nasal tuberculosis was diagnosed and successfully treated with standard anti-tubercular therapy.

## Contribution

This paper presents a rare clinical case of primary nasal TB without pulmonary involvement.

## Key findings

- Nasal endoscopy and biopsy confirmed primary nasal TB with caseating granulomas and acid-fast bacilli.
- Standard anti-tubercular treatment resolved symptoms completely with no recurrence after one year.

## Abstract

Primary nasal tuberculosis (TB) is an exceedingly rare form of extrapulmonary TB, often mimicking other granulomatous diseases and posing diagnostic challenges. We present a case of a 54-year-old female patient with persistent nasal obstruction and epistaxis, initially suspected to be chronic rhinosinusitis. Diagnostic evaluation, including nasal endoscopy and biopsy, revealed caseating granulomas with acid-fast bacilli (AFB), confirming primary nasal TB without pulmonary involvement. The patient was treated with a standard anti-tubercular regimen of two months of intensive phase (four drugs) and four months of continuation phase (three drugs), resulting in complete resolution of symptoms and no recurrence at one-year follow-up. This case underscores the importance of considering TB in atypical nasal presentations, especially in endemic regions, and highlights the efficacy of timely anti-tuberculous therapy.

## Linked entities

- **Diseases:** tuberculosis (MONDO:0018076), chronic rhinosinusitis (MONDO:0006031)

## Full-text entities

- **Diseases:** Primary Nasal Tuberculosis (MESH:D014376), granulomas (MESH:D006099), granulomatous diseases (MESH:D006105), tubercular (MESH:D014390), epistaxis (MESH:D004844), pulmonary involvement (MESH:C566343), nasal obstruction (MESH:D015508), rhinosinusitis (MESH:D000092562)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Full text

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## Figures

4 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12888061/full.md

## References

9 references — full list in the complete paper: https://tomesphere.com/paper/PMC12888061/full.md

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Source: https://tomesphere.com/paper/PMC12888061