# Pentafluoroethyl Sulfoximine Reagent for the Photocatalytic Pentafluoroethylation–Difunctionalization of Styrene Derivatives

## TL;DR

A new reagent enables the efficient addition of a pentafluoroethyl group to styrene derivatives under mild conditions, forming multiple bonds.

## Contribution

A novel pentafluoroethyl sulfoximine reagent is introduced for photocatalytic difunctionalization of styrenes.

## Key findings

- The sulfoximine reagent serves as a source of pentafluoroethyl radical under mild photocatalytic conditions.
- The method allows the formation of C–O/C–N/C–S/C–C bonds alongside pentafluoroethylation of styrenes.
- This approach expands the scope of difunctionalization compared to traditional copper-based methods.

## Abstract

We herein describe the synthesis of a pentafluoroethyl
sulfoximine
and its application in the pentafluoroethylation–difunctionalization
of styrene derivatives. This sulfoximine reagent acts as a source
of pentafluoroethyl radical to react with styrenes under mild photocatalytic
conditions. By using simple nucleophiles, the pentafluoroethyl group
can be introduced to styrenes with concomitant formation of C–O/C–N/C–S/C–C
bonds, which significantly broadens the difunctionalization scope
involving pentafluoroethylation compared to previous copper-based
methods.