# Enantioselective α,α-Chlorofluorination of Sulfoxonium Ylides

## TL;DR

This paper reports a new method for creating chiral gem-dihalogenated compounds with high efficiency and enantioselectivity.

## Contribution

The paper introduces enantioselective α,α-chlorofluorination using chiral aminosulfoxonium ylides and fluorinating reagents from cinchona alkaloids.

## Key findings

- 25 examples of gem-dihalogenated compounds were synthesized with up to 90% yield.
- Enantioselectivity reached up to 96:4 er using chiral fluorinating reagents.
- The method includes bromochlorination and is derived from commercially available cinchona alkaloids.

## Abstract

The first examples
of enantioselective α,α-chlorofluorination
of α-carbonylsulfoxonium ylides are described. Herein, two modes
of reaction are explored, using chiral aminosulfoxonium ylides and
a chiral fluorinating reagent, prepared in situ from
commercially available cinchona alkaloids. Using these approaches,
25 examples of gem-dihalogenated compounds (including bromochlorination)
were obtained in good yields (up to 90%) and enantioselectivity (up
to 96:4 er).