# Catalytic Hydrophosphorylation of Propiolates and Three-Component Phosphorylation of Aldehydes

## TL;DR

This paper introduces efficient methods for hydrophosphorylation reactions using DABCO and H-phosphonates, enabling straightforward synthesis of phosphorylated compounds.

## Contribution

The novelty lies in the regio- and stereoselective hydrophosphorylation of propiolates and a three-component phosphorylation of aldehydes using DABCO.

## Key findings

- DABCO catalyzes hydrophosphorylation of propiolates with high regio- and stereoselectivity.
- A three-component phosphorylation of aldehydes is achieved with atom economy and simple procedures.
- H-phosphonates serve as effective phosphorylating agents in these reactions.

## Abstract

A practical and efficient regio- and stereoselective
hydrophosphorylation
of propiolates, as well as a multicomponent reaction incorporating
an aldehyde component, is reported. Both processes proceed with atom
economy in very straightforward experimental procedures. The reactions
are catalyzed by DABCO (1,4-diazabicyclo[2.2.2]­octane) and use readily
available H-phosphonates as the phosphorylating agent.