# Prognostic Value of Elevated miR‐502‐3p in Patients With Post‐Stroke Cognitive Impairment

## TL;DR

This study shows that high levels of miR-502-3p in the blood can predict cognitive problems after a stroke.

## Contribution

The study identifies miR-502-3p as a novel biomarker for predicting post-stroke cognitive impairment.

## Key findings

- Elevated miR-502-3p levels were significantly associated with post-stroke cognitive impairment.
- miR-502-3p showed 76.79% sensitivity and 77.64% specificity in predicting PSCI.
- miR-502-3p was positively correlated with NIHSS and mRS scores but negatively with MoCA scores.

## Abstract

Post‐stroke cognitive impairment (PSCI) is a common complication following a stroke. Recent findings highlight the role of miR‐502‐3p in both vascular and neurodegenerative diseases. However, the role in PSCI remains uncovered.

This study emphasized the differential expression of miR‐502‐3p and subsequently evaluated the predictive value of miR‐502‐3p expression levels for PSCI.

The study subjects included 112 patients with PSCI and 161 individuals with post‐stroke cognitive normality. The relative expression of miR‐502‐3p was calculated by qPCR, while its predictive value for PSCI was assessed via ROC curve. Pearson's correlation coefficient was utilized to analyze the correlation between serum miR‐502p‐3p levels and PSCI. Multivariate logistic regression was used to identify risk factors of PSCI.

Serum miR‐502‐3p was identified as significantly elevated in the PSCI group. The area under the ROC curve was 0.850, with a sensitivity of 76.79% and a specificity of 77.64%. The miR‐502‐3p level was positively correlated with both NIHSS and mRS scores. In addition, a negative correlation was observed between the miR‐502‐3p level and MoCA score. Elevated miR‐502‐3p and hypertension were identified as independent risk factors for PSCI.

Significantly elevated serum miR‐502‐3p was a promising biomarker for the onset of PSCI. Elevated miR‐502‐3p and hypertension were independent risk factors for PSCI.

Significantly elevated serum miR‐502‐3p was positively correlated with both NIHSS and mRS scores, while it was negatively related to the MoCA score. Furthermore, the serum miR‐502‐3p was identified as a promising biomarker post‐stroke cognitive impairment (PSCI). Multivariate logistic regression confirmed it as an independent risk factor for PSCI.