This paper is marked retracted in the scholarly record (OpenAlex). Interpret its findings with caution.
Retraction: Ribosomal L22-like1 (RPL22L1) Promotes Ovarian Cancer Metastasis by Inducing Epithelial-to-Mesenchymal Transition

Abstract
Genes, proteins, chemicals, diseases, species, mutations and cell lines named across the full text — each resolved to its canonical identifier and authoritative record.
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Taxonomy
TopicsRNA modifications and cancer · RNA and protein synthesis mechanisms · Cancer-related molecular mechanisms research
After this article [1] was published, concerns were raised about Fig 4, and subsequent editorial assessment identified additional issues. Specifically,
In light of the cumulative concerns, which call into question the reliability of the reported results, the PLOS One Editors retract this article.
The PLOS One Editors additionally note that the quantitative data underlying the results reported for the experiments in cell lines have not been provided within the paper or its Supporting Information files, as indicated in the Data Availability statement. As such, the article does not appear to meet the requirements of the Data Availability policy in place at the time of submission. However, the corresponding author indicated on follow-up that the complete underlying quantitative data could be provided; as such, PLOS considers that this issue potentially could have been resolved, and it did not contribute to the final decision to retract.
NW, JW, YW, JY, YQ, BP, DS, HS, YY, WS, XM, CZ, JB, FC, SF, and YJ did not agree with the retraction and stand by the article’s findings. DT, JG, and KYL either did not respond directly or could not be reached.
The reference list from the paper itself. Each links out to its DOI / PubMed record.
- 1Wu N, Wei J, Wang Y, Yan J, Qin Y, Tong D, et al. RETRACTED: Ribosomal L 22-like 1 (RPL 22L 1) Promotes Ovarian Cancer Metastasis by Inducing Epithelial-to-Mesenchymal Transition. P Lo S One. 2015;10(11):e 0143659. doi: 10.1371/journal.pone.0143659 26618703 PMC 4664398 · doi ↗ · pubmed ↗
- 2Capes-Davis A, Theodosopoulos G, Atkin I, Drexler HG, Kohara A, Mac Leod RAF, et al. Check your cultures! A list of cross-contaminated or misidentified cell lines. Int J Cancer. 2010;127(1):1–8. doi: 10.1002/ijc.25242 20143388 · doi ↗ · pubmed ↗
- 3Bairoch A. The Cellosaurus, a Cell-Line Knowledge Resource. J Biomol Tech. 2018;29(2):25–38. doi: 10.7171/jbt.18-2902-002 29805321 PMC 5945021 · doi ↗ · pubmed ↗
- 4Ye F, Chen C, Qin J, Liu J, Zheng C. Genetic profiling reveals an alarming rate of cross-contamination among human cell lines used in China. FASEB J. 2015;29(10):4268–72. doi: 10.1096/fj.14-266718 26116706 · doi ↗ · pubmed ↗
- 5Bian X, Yang Z, Feng H, Sun H, Liu Y. A Combination of Species Identification and STR Profiling Identifies Cross-contaminated Cells from 482 Human Tumor Cell Lines. Sci Rep. 2017;7(1):9774. doi: 10.1038/s 41598-017-09660-w 28851942 PMC 5575032 · doi ↗ · pubmed ↗
