# Gut microbiota and postoperative complications in colorectal surgery and its potential association with intestinal permeability and NLRP6 inflammasome

## TL;DR

This paper reviews how gut microbiota changes and inflammasome activation may contribute to postoperative complications like anastomotic leakage in colorectal surgery.

## Contribution

The paper provides a novel analysis of the interplay between intestinal permeability, dysbiosis, and inflammasome pathways in postoperative inflammation.

## Key findings

- Surgical trauma can alter gut microbiota and epithelial barrier function.
- Inflammasomes like NLRP3, NLRC4, and NLRP6 may mediate postoperative inflammation.
- Understanding these pathways could help identify patients at risk for complications.

## Abstract

This manuscript reviews the current evidence describing the relationships between surgical trauma, altered intestinal permeability, dysbiosis, inflammasome activation, and postoperative inflammation in the development of AL. Surgical tissue disruption and anastomosis creation can modify the intestinal microbiota and compromise epithelial barrier function, promoting a proinflammatory environment mediated by inflammasomes such as NLRP3, NLRC4, and NLRP6. This review analyses the inflammatory pathways that may regulate intestinal homeostasis, their potential contribution to postoperative complications such as AL, and how these insights may guide future preventive strategies or help identify patients at increased risk.