# Survival Outcomes and Clinicopathologic Prognostic Factors in Gastric Cancer: A Small Single-Center Retrospective Cohort From Eastern Türkiye

## TL;DR

This study examines survival and prognostic factors in gastric cancer patients from eastern Türkiye, finding modest survival rates and inconclusive associations due to a small sample size.

## Contribution

The paper provides real-world gastric cancer survival data from eastern Türkiye, highlighting the need for larger multicenter studies.

## Key findings

- Median overall survival was not reached with 12- and 24-month survival rates of 71.1% and 62.2%.
- Older age showed a borderline association with worse survival in univariate analysis.
- The study found inconclusive associations between clinicopathologic factors and survival due to limited statistical power.

## Abstract

Introduction: Real-world data from eastern Türkiye regarding gastric cancer outcomes remain limited. We aimed to describe overall survival (OS) and explore associations between OS and key clinicopathologic factors in a small, single-center cohort.

Methods: We retrospectively reviewed consecutive adults with gastric adenocarcinoma who underwent gastrectomy with curative intent between January 2019 and June 2025. Perioperative mortality (<30 days) was excluded to focus on long-term oncologic outcomes. OS was defined from surgery to death from any cause; survivors were administratively censored at June 2, 2025. Kaplan-Meier methods and univariate Cox models were used.

Results: Thirty patients were included (mean age 65.8±9.4 years; 20/30 male). Median follow-up among survivors was 19.2 months (IQR 8.2-30.8). Twelve- and 24-month OS were 71.1% and 62.2%, respectively; median OS was not reached. Median retrieved lymph nodes was 20 (IQR 19-36; range 4-61). Median lymph node ratio (LNR) was 0.09 (IQR 0.04-0.21). Older age showed a borderline association with worse OS in univariate Cox analysis.

Conclusions: In this small exploratory cohort, OS estimates were modest and associations with clinicopathologic variables were largely inconclusive due to limited power. Larger, multicenter cohorts with standardized reporting of histology, staging, and perioperative treatment are required.