# Incidence of acute kidney injury among high-risk adult patients undergoing iso-osmolar contrasted computed tomography scans: a prospective cohort study

## TL;DR

This study found a 9% incidence of kidney injury in high-risk patients after using iso-osmolar contrast for CT scans, with no clear risk factors identified.

## Contribution

The study provides new empirical data on CIAKI incidence with iso-osmolar contrast in high-risk patients.

## Key findings

- The cumulative incidence of CIAKI was 9% (20 out of 223 patients).
- No factors were independently associated with CIAKI in the study population.

## Abstract

The safety of iso-osmolar contrast media (IOCM) in patients at risk of contrast-induced kidney injury (CIAKI) is not well-established.

To determine the incidence of CIAKI among high-risk adult patients undergoing iso-osmolar contrasted Computed Tomography (CT) scans.

A prospective descriptive cohort study of patients at high risk of CIAKI was done. Questionnaires were used to collect clinical and examination findings. Blood samples were collected at baseline and at 48 hours post-administration of IOCM to assess changes in serum creatinine. Those found to have a ≥ 0.5mg/dl absolute increase in serum creatinine from the baseline within 48 hours of contrast administration were considered to have developed CIAKI. Pearson's Chi-square test was used to compare patients with and without CIAKI. Logistic regression models were used to determine associations of CIAKI.

The cumulative incidence of CIAKI was 9% (20/223), (95%CI – 5.8451-13.5215). No factors were independently associated with CIAKI in this study.

The incidence of CIAKI among high-risk adult patients undergoing CT scans was 9%. There were no factors significantly associated with CIAKI.