# Research Progress on the Mechanism of Gut Microbiota Influencing Lung Cancer Brain Metastasis via the Brain-gut Axis

## TL;DR

This paper reviews how gut microbiota may influence lung cancer brain metastasis through the brain-gut axis, offering new insights for treatment strategies.

## Contribution

The paper systematically summarizes the novel mechanisms by which gut microbiota regulate lung cancer brain metastasis via neuroendocrine-immune interactions.

## Key findings

- Gut microbiota may influence lung cancer brain metastasis through immune modulation.
- Endocrine and metabolic pathways mediated by the brain-gut axis are involved in cancer progression.
- Regulating gut microbiota could serve as a potential therapeutic target for lung cancer brain metastasis.

## Abstract

肺癌作为全球癌症死亡的主要原因之一，其并发症脑转移（以脑实质为主）严重影响患者的生活质量及预后。传统治疗手段，如手术、放疗及化疗，虽在临床实践中取得了一定疗效，却因毒性和患者耐受性问题而应用受限。新兴的靶向治疗与免疫治疗凭借较少的副作用展现出显著疗效，但仍然面临部分耐药及基因突变等挑战。近年来，肠道菌群与肺癌脑转移之间的关联性研究成为新热点，其作用机制可能通过脑-肠轴介导的神经内分泌-免疫多维度交互途径对肺癌脑转移进程产生影响。本文综述了肠道菌群基于脑-肠轴调控肺癌脑转移的免疫调节、内分泌代谢调节、神经递质调控等具体作用机制，及调节肠道菌群在肺癌脑转移中的治疗和传统医学研究，旨在为肺癌脑转移的防治策略提供理论支撑和临床潜在治疗靶点。