# Mechanisms of Exosomes in Lung Cancer Bone Metastasis and Related Clinical Advances

## TL;DR

This paper reviews how exosomes contribute to lung cancer bone metastasis and their potential for clinical applications.

## Contribution

The paper provides an updated overview of exosome mechanisms in lung cancer bone metastasis and their clinical implications.

## Key findings

- Exosomes mediate tumor-stroma and immune interactions in bone metastasis.
- Exosomes influence energy metabolism and pre-metastatic niche formation.
- Exosomes show potential for early diagnosis and treatment of bone metastasis.

## Abstract

肺癌是发病率和死亡率最高的恶性肿瘤，诊断时通常已形成晚期转移。肿瘤发生转移是其治疗效果差、生存期短的重要影响因素，其中骨转移是肺癌常见的转移形式，常引起骨痛、病理性骨折、神经压迫和高钙血症等骨相关事件，严重影响患者生活质量且预后极差。外泌体是由细胞内多囊泡体与细胞膜融合后，释放到细胞外形成的直径为40-160 nm的细胞外囊泡。其携带蛋白质、脂质和核酸等物质介导肿瘤细胞与基质细胞、免疫细胞及骨微环境之间的信息传递，在肿瘤发生发展及侵袭转移过程中发挥重要调控作用，因此日益受到研究者们的关注。本文旨在总结并梳理外泌体促进肺癌骨转移的最新研究进展，重点阐述其关键机制与信号通路，包括在原发灶促进肿瘤细胞增殖和侵袭转移，在远处骨转移定植过程中参与的能量代谢重编程、转移前微环境塑造、免疫微环境调控和骨细胞、基质细胞等互作，并进一步分析外泌体在肺癌骨转移早期诊断、治疗及预后等方面的潜在临床转化价值。

The research stage of exosomes and their related targets in bone metastasis of lung cancer and their potential clinical value

Inhibiting the release of metastasis-promoting exosomes or utilizing engineered exosomes for the treatment of lung cancer bone metastasis