# Exceptionally Long Recurrence‐Free Survival in a Male Patient With Fibrolamellar Hepatocellular Carcinoma

**Authors:** Elizabeth C. Townsend, Disha Sharma, Harish Gopalakrishna, Maria Mironova, David E. Kleiner, Theo Heller

PMC · DOI: 10.1155/crhe/7445319 · Case Reports in Hepatology · 2026-02-08

## TL;DR

A young male patient with a rare liver cancer called fibrolamellar hepatocellular carcinoma had no cancer recurrence for over 11 years after surgery, emphasizing the benefits of early detection and complete tumor removal.

## Contribution

Reports a rare case of exceptionally long recurrence-free survival in a male FLHCC patient following surgical resection.

## Key findings

- A male patient with fibrolamellar hepatocellular carcinoma remained recurrence-free for over 11 years after surgical resection.
- The case highlights the importance of early detection and complete tumor removal in improving outcomes for FLHCC patients.
- Regular post-resection surveillance is emphasized as critical for managing this aggressive cancer.

## Abstract

Fibrolamellar hepatocellular carcinoma (FLHCC) accounts for less than 1% of all primary liver cancers. Due to an absence of known risk factors, most individuals are diagnosed at advanced stages of disease. Subsequently, these tumors carry a 30%–50% mortality rate and a 33%–100% recurrence rate in those treated with curative intent. Here, we describe an incidental discovery of an FLHCC tumor in a young male patient, who following surgical resection has remained recurrence free for over 11 years. This exceptionally long recurrence‐free survival highlights the advantage of early‐stage detection, the benefit of complete tumor resection, and further underscores the importance of regular postresection cancer surveillance.

## Linked entities

- **Diseases:** fibrolamellar hepatocellular carcinoma (MONDO:0006210), liver cancer (MONDO:0002691)

## Full-text entities

- **Diseases:** FLHCC (MESH:C537258), liver cancers (MESH:D006528), cancer (MESH:D009369)
- **Species:** Homo sapiens (human, species) [taxon 9606]

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## References

28 references — full list in the complete paper: https://tomesphere.com/paper/PMC12883663/full.md

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Source: https://tomesphere.com/paper/PMC12883663