# Successful Vaginal Delivery in a Pregnant Woman With Bernard–Soulier Syndrome: A Case Report

**Authors:** Monireh Yaghoubi, Nona Sabeti, Ezat Hajmollarezaei

PMC · DOI: 10.1002/ccr3.71706 · Clinical Case Reports · 2026-02-08

## TL;DR

A woman with a rare blood disorder successfully delivered a baby vaginally through careful planning and medical coordination.

## Contribution

Demonstrates that vaginal delivery is feasible for Bernard–Soulier syndrome patients with proper multidisciplinary care.

## Key findings

- A 23-year-old woman with BSS had a successful full-term vaginal delivery.
- Prophylactic platelet transfusions and timely interventions prevented severe bleeding.
- Cesarean section is not the only option for high-risk hematologic conditions.

## Abstract

Bernard–Soulier syndrome (BSS) is a rare inherited platelet disorder that poses major risks during pregnancy because of potential bleeding complications. Managing such cases in low‐resource settings is especially challenging. We report the case of a 23‐year‐old Afghan woman with BSS who achieved a successful full‐term vaginal delivery at a tertiary center. Early referral, coordinated management by hematology and obstetric teams, prophylactic platelet transfusions, and prompt treatment of postpartum hemorrhage led to a favorable maternal and neonatal outcome. This experience shows that, even where advanced laboratory and transfusion resources are limited, structured planning, timely communication, and preparedness can ensure a safe delivery for women with complex hematologic disorders.

A multidisciplinary strategy combining prophylactic platelet transfusion, tranexamic acid, and uterotonic agents enabled a safe vaginal delivery in a patient with Bernard–Soulier syndrome, indicating that cesarean section is not the only option in such high‐risk hematologic conditions.

## Linked entities

- **Diseases:** Bernard–Soulier syndrome (MONDO:0009276)
- **Species:** Homo sapiens (taxon 9606)

## Full-text entities

- **Diseases:** bleeding (MESH:D006470), hematologic disorders (MESH:D006402), inherited platelet disorder (MESH:D001791), postpartum hemorrhage (MESH:D006473), BSS (MESH:D001606)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Full text

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## References

12 references — full list in the complete paper: https://tomesphere.com/paper/PMC12883334/full.md

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Source: https://tomesphere.com/paper/PMC12883334