# Early-Onset Myocardial Infarction in Adults Under 45: A Review of Five Cases

**Authors:** Samy Matta, Tambi Isaac, Roxana Lazarescu, Mujtaba Zafar, Hejmadi Prabhu

PMC · DOI: 10.7759/cureus.101119 · Cureus · 2026-01-08

## TL;DR

This paper reviews five cases of heart attacks in adults under 45, highlighting the need for tailored diagnosis and management.

## Contribution

The study provides insights into the clinical presentation and risk factors of early-onset myocardial infarction in young adults.

## Key findings

- Early-onset MI predominantly occurred in males with conventional risk factors.
- Coronary angiography showed both single- and multi-vessel disease in patients.
- Incomplete follow-up data underscored the need for individualized long-term management.

## Abstract

Myocardial infarction (MI) in individuals younger than 45 years is uncommon but carries significant clinical and psychosocial implications. Its presentation challenges traditional assumptions regarding cardiovascular risk and necessitates tailored approaches to diagnosis and management. We conducted a retrospective analysis of five patients aged <45 years admitted to a local hospital in New York with confirmed MI. Data included comorbidities, imaging, laboratory results, angiographic findings, and treatment modalities. Early-onset MI occurred predominantly in males, most of whom exhibited conventional risk factors. Coronary angiography revealed both single- and multi-vessel disease. Follow-up data were incomplete, with two patients lost to follow-up. These findings highlight the importance of recognizing conventional risk factors in younger populations and emphasize the need for individualized long-term management strategies.

## Linked entities

- **Diseases:** Myocardial infarction (MONDO:0005068), Myocardial infarction (MONDO:0005068)

## Full-text entities

- **Diseases:** single- and multi-vessel disease (MESH:D012640), MI (MESH:D009203)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Full text

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## Figures

12 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12883222/full.md

## References

15 references — full list in the complete paper: https://tomesphere.com/paper/PMC12883222/full.md

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Source: https://tomesphere.com/paper/PMC12883222