# A Medically Managed Case of Acromegaly: A Case Report

**Authors:** Karam Bdour, Khaldon Al-Sarihin, Nesreen El Issa, Odai Alwraikat, Mohammad Albadarneh, Rania Al-Asa'd, Mu'taz Alwadi

PMC · DOI: 10.7759/cureus.101136 · Cureus · 2026-01-09

## TL;DR

This case report describes a 39-year-old man with acromegaly successfully treated with medical therapy, showing improvement in hormone levels and tumor size.

## Contribution

The novelty lies in demonstrating the effectiveness of combined medical therapy for a large pituitary tumor without surgery.

## Key findings

- The patient showed significant biochemical and anatomical improvement with medical therapy.
- Combined use of somatostatin analogs and dopamine agonists was effective in managing the tumor.

## Abstract

Endocrine glands are specialized cells responsible for producing and secreting hormones that serve many functions in various body tissues. The pituitary gland is an endocrine gland located in the brain, composed of anterior and posterior parts, both of which are responsible for the secretion of many hormones. The anterior pituitary gland secretes six hormones. Hypersecretion and undersecretion result in abnormalities in the body. Autonomous growth hormone production due to a pituitary adenoma leads to various changes in tissues and organs. Excess growth hormone results in gigantism during childhood, while in adulthood, it is called acromegaly. In this report, we present a 39-year-old man with a large somatotroph macroadenoma, which was managed entirely with medical therapy, resulting in significant biochemical and anatomical improvement. This case highlights the potential role of combined somatostatin analogs and dopamine agonists in selected patients with acromegaly.

## Linked entities

- **Diseases:** acromegaly (MONDO:0019933)

## Full-text entities

- **Diseases:** Excess growth hormone (MESH:C531600), pituitary adenoma (MESH:D010911), Acromegaly (MESH:D000172), Hypersecretion (MESH:D006966), gigantism (MESH:D005877)
- **Chemicals:** somatostatin analogs (-)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Full text

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## Figures

5 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12883221/full.md

## References

30 references — full list in the complete paper: https://tomesphere.com/paper/PMC12883221/full.md

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Source: https://tomesphere.com/paper/PMC12883221