# Systemic lupus erythematosus extends beyond a type I interferonopathy, as demonstrated by NET‐activated monocytes **Authors:** Xiaolin Cao, Niels van Heusden, Daan K. J. Pieren, Bettina C. Geertsema‐Hoeve, Ellen D. Kaan, Patrick F. Greve, Maarten Limper, Marianne Boes PMC · DOI: 10.1002/ctm2.70599 · Clinical and Translational Medicine · 2026-02-08 ## Full-text entities - **Genes:** IL7 (interleukin 7) [NCBI Gene 3574] {aka IL-7, IMD130}, IFNG (interferon gamma) [NCBI Gene 3458] {aka IFG, IFI, IMD69}, IL4 (interleukin 4) [NCBI Gene 3565] {aka BCGF-1, BCGF1, BSF-1, BSF1, IL-4}, CD86 (CD86 molecule) [NCBI Gene 942] {aka B7-2, B7.2, B70, BU63, CD28LG2, CD86 v6}, CCL2 (C-C motif chemokine ligand 2) [NCBI Gene 6347] {aka GDCF-2, HC11, HSMCR30, MCAF, MCP-1, MCP1}, IL15 (interleukin 15) [NCBI Gene 3600] {aka IL-15}, IL2 (interleukin 2) [NCBI Gene 3558] {aka IL-2, TCGF, lymphokine}, CCL5 (C-C motif chemokine ligand 5) [NCBI Gene 6352] {aka D17S136E, RANTES, SCYA5, SIS-delta, SISd, TCP228}, CSF2 (colony stimulating factor 2) [NCBI Gene 1437] {aka CSF, GMCSF}, FCGR3A (Fc gamma receptor IIIa) [NCBI Gene 2214] {aka CD16-II, CD16A, FCG3, FCGR3, FCRIIIA, FcGRIIIA}, IFNA1 (interferon alpha 1) [NCBI Gene 3439] {aka IFL, IFN, IFN-ALPHA, IFN-alphaD, IFNA13, IFNA@}, IL1B (interleukin 1 beta) [NCBI Gene 3553] {aka IL-1, IL1-BETA, IL1F2, IL1beta}, IFNAR1 (interferon alpha and beta receptor subunit 1) [NCBI Gene 3454] {aka AVP, CRF2-1, IFN-R-1, IFN-alpha-REC, IFNAR, IFNBR}, CD4 (CD4 molecule) [NCBI Gene 920] {aka CD4mut, IMD79, Leu-3, OKT4D, T4}, TNF (tumor necrosis factor) [NCBI Gene 7124] {aka DIF, IMD127, TNF-alpha, TNFA, TNFSF2, TNLG1F}, IL6 (interleukin 6) [NCBI Gene 3569] {aka BSF-2, BSF2, CDF, HGF, HSF, IFN-beta-2}, CXCL8 (C-X-C motif chemokine ligand 8) [NCBI Gene 3576] {aka GCP-1, GCP1, IL8, LECT, LUCT, LYNAP}, CD28 (CD28 molecule) [NCBI Gene 940] {aka IMD123, Tp44}, IL2RA (interleukin 2 receptor subunit alpha) [NCBI Gene 3559] {aka CD25, IDDM10, IL2R, IMD41, TCGFR, p55}, CCR5 (C-C motif chemokine receptor 5) [NCBI Gene 1234] {aka CC-CKR-5, CCCKR5, CCR-5, CD195, CKR-5, CKR5}, CD80 (CD80 molecule) [NCBI Gene 941] {aka B7, B7-1, B7.1, BB1, CD28LG, CD28LG1}, CD69 (CD69 molecule) [NCBI Gene 969] {aka AIM, BL-AC/P26, CLEC2C, EA1, GP32/28, MLR-3}, CD14 (CD14 molecule) [NCBI Gene 929] - **Diseases:** NET (MESH:C536657), HD (MESH:D000067329), antiphospholipid syndrome (MESH:D016736), inflammatory (MESH:D007249), SLE (MESH:D008180), type I interferonopathy (MESH:D006969) - **Chemicals:** LPS (MESH:D008070), Anifrolumab (MESH:C582345) - **Species:** Homo sapiens (human, species) [taxon 9606] ## Full text _Full body text omitted from this summary view._ Fetch the complete paper as Markdown: https://tomesphere.com/paper/PMC12883034/full.md ## Figures 4 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12883034/full.md ## References 10 references — full list in the complete paper: https://tomesphere.com/paper/PMC12883034/full.md --- Source: https://tomesphere.com/paper/PMC12883034