# Neuromodulation With Electromagnetic Field Stimulation via Gamma Oscillations Improved Mini-Mental State Examination Scores in Patients With Cognitive Impairment

## TL;DR

This pilot study explores using electromagnetic field stimulation at gamma frequencies to improve cognitive function in patients with cognitive impairment, showing a trend toward better scores on a cognitive test.

## Contribution

A novel approach using EMF stimulation at 70-100 Hz to modulate gamma oscillations and assess cognitive improvement in patients with cognitive impairment.

## Key findings

- Post-stimulation MMSE scores improved from 13.8 to 17.5 out of 30, though not statistically significant.
- EMF stimulation led to observable changes in brain EMF waves.
- The study refined protocols for EMF recording and stimulation.

## Abstract

Background: Abnormalities in gamma oscillations have been found in neurological disorders that involve dementia, such as Alzheimer’s disease. Neuromodulation via gamma stimulation has shown promising potential to enhance cognitive function in patients with Alzheimer’s disease.

Objective: In this pilot clinical trial, we describe recording and neuromodulation of brain electromagnetic field (EMF) at gamma oscillations, specifically 70 Hertz (Hz) to 100 Hz, and its effect on brain EMF waves, cognition, and memory as assessed with EMF recordings and Mini-Mental State Examination (MMSE) in patients with cognitive impairment. We hypothesize that EMF stimulation at 70-100 Hz will lead to a statistically significant improvement in MMSE compared with baseline. Additionally, we aim to refine EMF recording and stimulation protocols.

Methods: MMSE was performed before and after EMF recordings. We used a previously developed portable helmet system equipped with Mu-metal (MuMETAL, Magnetic Shield Corporation, Bensenville, IL) and copper shielding, embedded sensors, and EMF generators to record baseline brain EMF of patients with cognitive impairment, identify the sensor of interest and frequency of interest, deliver EMF stimulation at the frequency of interest at 10 Volts over 10 minutes, and record post-stimulation EMF.

Results: Sixteen patients with cognitive impairment were included in this study. EMF recordings from six patients were used to refine analysis protocols, while ten new patients underwent stimulation. The mean pre-stimulation MMSE score was 13.8/30 points, and the mean post-stimulation MMSE score was 17.5/30 points (p=0.170).

Conclusions: In this pilot study, neuromodulation via EMF stimulation led to improvement in EMF waves and showed a trend toward cognitive and memory improvement without statistical significance in patients with cognitive impairment.