# Clinical Presentation and Management of Tubulointerstitial Nephritis and Uveitis Syndrome: A Case Series

## TL;DR

This paper presents four cases of TINU syndrome, a rare condition affecting the kidneys and eyes, to improve understanding of its diagnosis and management.

## Contribution

The study contributes a case series highlighting the varied clinical presentations and management of TINU syndrome.

## Key findings

- TINU syndrome often presents with asynchronous kidney and eye symptoms, complicating diagnosis.
- The cases highlight the importance of excluding other systemic diseases for accurate diagnosis.
- Management outcomes varied, emphasizing the need for individualized treatment approaches.

## Abstract

Tubulointerstitial nephritis and uveitis (TINU) syndrome is a rare systemic inflammatory condition characterized by oculorenal involvement. The pathophysiology is not fully understood but is thought to involve an immune-mediated response, potentially triggered by infections, medications, or genetic factors. TINU syndrome is often challenging to diagnose due to the asynchronous presentation of ocular and renal manifestations, requiring the exclusion of other systemic diseases. We present a four-case series of TINU syndrome, diagnosed between 2014 and 2024 at a tertiary center, highlighting the diversity in clinical presentations and outcomes, with the aim of bringing the authors’ experience in the diagnosis and management of this still underrecognized syndrome.