# Therapeutic targeting of Aurora Kinase A in advanced prostate cancer

**Authors:** Maroun Bou Zerdan, Mehmet Asim Bilen, Jindan Yu

PMC · DOI: 10.17161/sjm.v2i2.23274 · Serican journal of medicine · 2026-02-08

## Full-text entities

- **Genes:** COL11A2 (collagen type XI alpha 2 chain) [NCBI Gene 1302] {aka DFNA13, DFNB53, FBCG2, HKE5, OSMEDA, OSMEDB}, CHGA (chromogranin A) [NCBI Gene 1113] {aka CGA, PHE5, PHES}, ARRB1 (arrestin beta 1) [NCBI Gene 408] {aka ARB1, ARR1}, CCND1 (cyclin D1) [NCBI Gene 595] {aka BCL1, D11S287E, PRAD1, U21B31}, SSB (small RNA binding exonuclease protection factor La) [NCBI Gene 6741] {aka LARP3, La, La/SSB, SSB/La}, NKX3-1 (NK3 homeobox 1) [NCBI Gene 4824] {aka BAPX2, NKX3, NKX3.1, NKX3A}, MDM2 (MDM2 proto-oncogene) [NCBI Gene 4193] {aka ACTFS, HDMX, LSKB, hdm2}, SOX2 (SRY-box transcription factor 2) [NCBI Gene 6657] {aka ANOP3, MCOPS3}, EZH2 (enhancer of zeste 2 polycomb repressive complex 2 subunit) [NCBI Gene 2146] {aka ENX-1, ENX1, EZH2b, KMT6, KMT6A, WVS}, MYCN (MYCN proto-oncogene, bHLH transcription factor) [NCBI Gene 4613] {aka FGLDS1, MODED, MPAPA, MYCNsORF, MYCNsPEP, N-myc}, TP53 (tumor protein p53) [NCBI Gene 7157] {aka BCC7, BMFS5, LFS1, P53, TRP53}, RB1 (RB transcriptional corepressor 1) [NCBI Gene 5925] {aka OSRC, PPP1R130, RB, p105-Rb, p110-RB1, pRb}, PTEN (phosphatase and tensin homolog) [NCBI Gene 5728] {aka 10q23del, BZS, CWS1, DEC, GLM2, MHAM}, AR (androgen receptor) [NCBI Gene 367] {aka AIS, AR8, DHTR, HPCX3, HUMARA, HYSP1}, SYP (synaptophysin) [NCBI Gene 6855] {aka MRX96, MRXSYP, XLID96}, ARRB2 (arrestin beta 2) [NCBI Gene 409] {aka ARB2, ARR2, BARR2}, PLK1 (polo like kinase 1) [NCBI Gene 5347] {aka PLK, STPK13}, ACKR3 (atypical chemokine receptor 3) [NCBI Gene 57007] {aka CMKOR1, CXC-R7, CXCR-7, CXCR7, GPR159, RDC-1}, ASCL1 (achaete-scute family bHLH transcription factor 1) [NCBI Gene 429] {aka ASH1, HASH1, MASH1, bHLHa46}, AURKA (aurora kinase A) [NCBI Gene 6790] {aka AIK, ARK1, AURA, BTAK, PPP1R47, STK15}, H3P16 (H3 histone pseudogene 16) [NCBI Gene 644914] {aka H3.6, H3F3AP6, p21}, HNRNPK (heterogeneous nuclear ribonucleoprotein K) [NCBI Gene 3190] {aka AUKS, CSBP, HNRPK, TUNP}, MYC (MYC proto-oncogene, bHLH transcription factor) [NCBI Gene 4609] {aka MRTL, MYCC, bHLHe39, c-Myc}
- **Diseases:** tumorigenesis (MESH:D063646), BRCA-mutant cancers (MESH:D001943), toxicity (MESH:D064420), CRPC (MESH:D064129), prostate adenocarcinoma (MESH:D000230), HR-deficient PCa (MESH:D011471), small cell lung cancer (MESH:D055752), cancer (MESH:D009369), HR deficiency (MESH:C535296), metastasis (MESH:D009362)
- **Chemicals:** Olaparib (MESH:C531550), alisertib (MESH:C550258), ARPi (-), Enzalutamide (MESH:C540278)
- **Species:** Homo sapiens (human, species) [taxon 9606]

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## References

35 references — full list in the complete paper: https://tomesphere.com/paper/PMC12881931/full.md

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Source: https://tomesphere.com/paper/PMC12881931