# Insights Into circRNA‐Mediated Lipid Metabolism in Cancer Progression **Authors:** Zhiwei Miao, Jingjing Cao, Xiaoyu Wang, Chunyu Zhang, Tongguo Shi PMC · DOI: 10.1111/jcmm.71052 · Journal of Cellular and Molecular Medicine · 2026-02-07 ## TL;DR This paper explores how circular RNAs influence lipid metabolism in cancer, offering new insights into cancer progression and potential therapies. ## Contribution The paper introduces new understanding of circRNA roles in cancer lipid metabolism and their regulatory mechanisms. ## Key findings - CircRNAs play regulatory roles in lipid metabolism reprogramming in cancer cells. - Understanding circRNA mechanisms could lead to new targeted cancer therapies. ## Abstract Lipid metabolism reprogramming is one of the most prominent characteristics of cancer, but it is still unclear which regulatory pathways underlie this process in cancer cells. Circular RNAs (circRNAs) represent a novel category of non‐coding RNAs with multifaceted regulatory functions. While the biological roles of circRNAs in cancer have been elucidated, there remains a dearth of knowledge regarding their involvement and regulatory mechanisms in lipid metabolism within the context of cancer. This article provides an overview of the regulatory roles and specific mechanisms of circRNAs in cancer lipid metabolism reprogramming. By elucidating these mechanisms, it enhances our comprehension of the metabolic rewiring driving tumour development and uncovers new avenues for targeted therapy. ## Linked entities - **Diseases:** cancer (MONDO:0004992) ## Full-text entities - **Genes:** GPLD1 (glycosylphosphatidylinositol specific phospholipase D1) [NCBI Gene 2822] {aka GPIPLD, GPIPLDM, PIGPLD, PIGPLD1, PLD}, CPT1A (carnitine palmitoyltransferase 1A) [NCBI Gene 1374] {aka CPT I, CPT1, CPT1-L, CPTI-L, L-CPT1}, MIR647 (microRNA 647) [NCBI Gene 693232] {aka MIRN647, hsa-mir-647}, ERBB2 (erb-b2 receptor tyrosine kinase 2) [NCBI Gene 2064] {aka CD340, HER-2, HER-2/neu, HER2, MLN 19, MLN-19}, SOAT1 (sterol O-acyltransferase 1) [NCBI Gene 6646] {aka ACACT, ACAT, ACAT-1, ACAT1, SOAT, STAT}, Muc1 (mucin 1, transmembrane) [NCBI Gene 17829] {aka CD227, EMA, Muc-1}, FABP3 (fatty acid binding protein 3) [NCBI Gene 2170] {aka FABP11, H-FABP, M-FABP, MDGI, O-FABP}, CREB1 (cAMP responsive element binding protein 1) [NCBI Gene 1385] {aka CREB, CREB-1}, Acaca (acetyl-Coenzyme A carboxylase alpha) [NCBI Gene 107476] {aka A530025K05Rik, Acac, Acc1, Gm738}, LPAR5 (lysophosphatidic acid receptor 5) [NCBI Gene 57121] {aka GPR92, GPR93, KPG_010, LPA5}, Scd1 (stearoyl-Coenzyme A desaturase 1) [NCBI Gene 20249] {aka Scd, Scd-1, ab}, MIR661 (microRNA 661) [NCBI Gene 724031] {aka MIRN661, hsa-mir-661}, NR1H3 (nuclear receptor subfamily 1 group H member 3) [NCBI Gene 10062] {aka LXR-a, LXRA, RLD-1}, SREBF2 (sterol regulatory element binding transcription factor 2) [NCBI Gene 6721] {aka SREBP-2, SREBP2, bHLHd2}, KHSRP (KH-type splicing regulatory protein) [NCBI Gene 8570] {aka FBP2, FUBP2, KSRP, p75}, HCAR1 (hydroxycarboxylic acid receptor 1) [NCBI Gene 27198] {aka FKSG80, GPR104, GPR81, HCA1, LACR1, TA-GPCR}, Yap1 (Yes1 associated transcriptional regulator) [NCBI Gene 363014] {aka YAP65, Yap}, GPCPD1 (glycerophosphocholine phosphodiesterase 1) [NCBI Gene 56261] {aka EDI3, GDE5, GDPD6, PREI4}, Slc7a4 (solute carrier family 7 (cationic amino acid transporter, y+ system), member 4) [NCBI Gene 224022], TRMT61A (tRNA methyltransferase 61A) [NCBI Gene 115708] {aka C14orf172, GCD14, Gcd14p, TRM61, hTRM61}, MIR320A (microRNA 320a) [NCBI Gene 407037] {aka MIRN320, MIRN320A, hsa-mir-320a, mir-320a}, PLIN1 (perilipin 1) [NCBI Gene 5346] {aka FPLD4, PERI, PLIN}, SQLE (squalene epoxidase) [NCBI Gene 6713], Fads2 (fatty acid desaturase 2) [NCBI Gene 56473] {aka 2900042M13Rik, Fads2a, Fadsd2}, PPARA (peroxisome proliferator activated receptor alpha) [NCBI Gene 5465] {aka NR1C1, PPAR, PPAR-alpha, PPARalpha, hPPAR}, MIR5572 (microRNA 5572) [NCBI Gene 100847042], Fasn (fatty acid synthase) [NCBI Gene 14104] {aka A630082H08Rik, FAS}, RIPK3 (receptor interacting serine/threonine kinase 3) [NCBI Gene 11035] {aka RIP3}, HNRNPC (heterogeneous nuclear ribonucleoprotein C) [NCBI Gene 3183] {aka HNRNP, HNRPC, MRD74, SNRPC}, STAT2 (signal transducer and activator of transcription 2) [NCBI Gene 6773] {aka IMD44, ISGF-3, P113, PTORCH3, STAT113}, Xrcc6 (X-ray repair cross complementing 6) [NCBI Gene 14375] {aka 70kDa, G22p1, Ku70}, Wnt2 (Wnt family member 2) [NCBI Gene 114487] {aka Wnt}, MIR637 (microRNA 637) [NCBI Gene 693222] {aka MIRN637, hsa-mir-637}, ITGAV (integrin subunit alpha V) [NCBI Gene 3685] {aka CD51, IDNDC, MSK8, VNRA, VTNR}, Akt1 (AKT serine/threonine kinase 1) [NCBI Gene 24185] {aka Akt}, PTK2 (protein tyrosine kinase 2) [NCBI Gene 5747] {aka FADK, FADK 1, FAK, FAK1, FRNK, PPP1R71}, ACACA (acetyl-CoA carboxylase alpha) [NCBI Gene 31] {aka ACAC, ACACAD, ACACalpha, ACC, ACC1, ACCA}, NR1H2 (nuclear receptor subfamily 1 group H member 2) [NCBI Gene 7376] {aka LXR-b, LXRB, NER, NER-I, RIP15, UNR}, PRKAA2 (protein kinase AMP-activated catalytic subunit alpha 2) [NCBI Gene 5563] {aka AMPK, AMPK2, AMPKa2, PRKAA}, ACSL4 (acyl-CoA synthetase long chain family member 4) [NCBI Gene 2182] {aka ACS4, FACL4, LACS4, MRX63, MRX68, XLID63}, EREG (epiregulin) [NCBI Gene 2069] {aka EPR, ER, Ep}, SLC27A2 (solute carrier family 27 member 2) [NCBI Gene 11001] {aka ACSVL1, FACVL1, FATP2, HsT17226, VLACS, VLCS}, RICTOR (RPTOR independent companion of MTOR complex 2) [NCBI Gene 253260] {aka AVO3, PIA, hAVO3}, NOP16 (NOP16 nucleolar protein) [NCBI Gene 51491] {aka HSPC111, HSPC185}, Srebf1 (sterol regulatory element binding transcription factor 1) [NCBI Gene 20787] {aka ADD1, SREBP1, bHLHd1}, RBM45 (RNA binding motif protein 45) [NCBI Gene 129831] {aka DRB1, RB-1}, HMGCR (3-hydroxy-3-methylglutaryl-CoA reductase) [NCBI Gene 3156] {aka LDLCQ3, LGMDR28, MYPLG}, FASN (fatty acid synthase) [NCBI Gene 2194] {aka FAS, OA-519, SDR27X1}, CUL5 (cullin 5) [NCBI Gene 8065] {aka CUL-5, VACM-1, VACM1}, PFKL (phosphofructokinase, liver type) [NCBI Gene 5211] {aka ATP-PFK, PFK-B, PFK-L}, PTBP1 (polypyrimidine tract binding protein 1) [NCBI Gene 5725] {aka HNRNP-I, HNRNPI, HNRPI, PTB, PTB-1, PTB-T}, Pik3cb (phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta) [NCBI Gene 85243], LDLR (low density lipoprotein receptor) [NCBI Gene 3949] {aka LDLCQ2}, LPL (lipoprotein lipase) [NCBI Gene 4023] {aka HDLCQ11, LIPD}, MTOR (mechanistic target of rapamycin kinase) [NCBI Gene 2475] {aka FRAP, FRAP1, FRAP2, RAFT1, RAPT1, SKS}, Elavl1 (ELAV like RNA binding protein 1) [NCBI Gene 15568] {aka 2410055N02Rik, HUR, Hua}, ASB6 (ankyrin repeat and SOCS box containing 6) [NCBI Gene 140459], Acly (ATP citrate lyase) [NCBI Gene 104112] {aka A730098H14Rik}, Ctnnb1 (catenin beta 1) [NCBI Gene 84353] {aka Catnb}, NFKB1 (nuclear factor kappa B subunit 1) [NCBI Gene 4790] {aka CVID12, EBP-1, KBF1, NF-kB, NF-kB1, NF-kappa-B1} - **Diseases:** oesophageal squamous cell carcinoma (MESH:D000077277), pancreatic cancer (MESH:D010190), thyroid carcinoma (MESH:D013964), OS (MESH:D012516), lymphatic metastasis (MESH:D008207), obesity (MESH:D009765), medulloblastoma (MESH:D008527), NSCLC (MESH:D002289), PTC (MESH:D000077273), CLL (MESH:D015461), acidosis (MESH:D000138), HCC (MESH:D006528), Cancer Drug Resistance (MESH:D009369), tumorigenic (MESH:D002471), melanoma (MESH:D008545), GC (MESH:D013274), BCa (MESH:D001749), Alzheimer's disease (MESH:D000544), ICC (MESH:D018281), liver metastasis (MESH:D009362), Pca (MESH:D011471), diabetes (MESH:D003920), hypoxia (MESH:D000860), cervical cancer (MESH:D002583), RCC (MESH:D002292), CRC (MESH:D015179), astroglioma (MESH:D001254), ESCC (MESH:D004938), metabolic dysfunctions (MESH:D008659), TNBC (MESH:D064726), tumorigenesis (MESH:D063646), breast cancer (MESH:D001943), LUAD (MESH:D000077192) - **Chemicals:** Lipid (MESH:D008055), FA (MESH:D005227), choline (MESH:D002794), AA (MESH:D016718), sn-glycero-3-phosphocholine (MESH:D005997), cholesterol esters (MESH:D002788), FA16:0 (-), sphingomyelin (MESH:D013109), squalene (MESH:D013185), sphingolipids (MESH:D013107), free fatty acids (MESH:D005230), endocannabinoid (MESH:D063388), ceramide (MESH:D002518), LPA (MESH:C032881), carnitine (MESH:D002331), malonyl-CoA (MESH:D008316), monounsaturated fatty acid (MESH:D005229), carbon (MESH:D002244), sterol (MESH:D013261), ND-630 (MESH:C000610197), tamoxifen (MESH:D013629), docetaxel (MESH:D000077143), pentose phosphate (MESH:D010428), PUFAs (MESH:D005231), sunitinib (MESH:D000077210), cordycepin (MESH:C058120), cisplatin (MESH:D002945), taurine (MESH:D013654), phosphatidylcholine (MESH:D010713), MVA (MESH:D008798), ATP (MESH:D000255), acyl-carnitine (MESH:C116917), 14,15-EET (MESH:C046782), TCA (MESH:D014233), CO2 (MESH:D002245), Acetyl-CoA (MESH:D000105), phospholipid (MESH:D010743), NADH (MESH:D009243), palmitate (MESH:D010168), glycerophospholipid (MESH:D020404), Cholesterol (MESH:D002784), FADH2 (MESH:C058805), acyl-CoA (MESH:D000214), triglyceride (MESH:D014280), 2,3-epoxy squalene (MESH:C520393), flavin adenine dinucleotide (MESH:D005182), 5-fluorouracil (MESH:D005472) - **Species:** Mus musculus (house mouse, species) [taxon 10090], Homo sapiens (human, species) [taxon 9606] - **Cell lines:** BCa — Mus musculus (Mouse), Spontaneously immortalized cell line (CVCL_S780), HCT116 — Homo sapiens (Human), Colon carcinoma, Cancer cell line (CVCL_0291), NF1-419 — Homo sapiens (Human), Finite cell line (CVCL_X131), U87 — Homo sapiens (Human), Glioblastoma, Cancer cell line (CVCL_0022) ## Full text _Full body text omitted from this summary view._ Fetch the complete paper as Markdown: https://tomesphere.com/paper/PMC12881924/full.md ## Figures 3 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12881924/full.md ## References 144 references — full list in the complete paper: https://tomesphere.com/paper/PMC12881924/full.md --- Source: https://tomesphere.com/paper/PMC12881924