# Pressure Measurements Obtained from Intraosseous Access: Potential Clinical Applications Explored Using a Porcine Model

## TL;DR

This study shows that intraosseous pressure can reflect arterial pressure and help identify asystole during emergencies, potentially improving CPR outcomes.

## Contribution

The study demonstrates that intraosseous pressure can be used to assess circulatory activity and detect asystole in clinical scenarios.

## Key findings

- Intraosseous pressure correlated strongly with arterial pressure under normal conditions and during CPR.
- Intraosseous pressure tracings can identify asystole, offering potential clinical benefits for CPR.
- Epinephrine administration disrupted the correlation between intraosseous and arterial pressures.

## Abstract

Intraosseous access, the fastest access in emergencies, is exclusively used for delivering medications or fluids. The correlation between intraosseous and arterial pressures remains unclear. This study aimed to explore this correlation at baseline and in various clinical scenarios (e.g., different heart rates, arrhythmias, asystolic arrest, and CPR). In 11 male Yorkshire pigs (73.4 ± 5.9 kg), femoral artery and tibial Intraosseous lines were placed under anesthesia. Pressures were recorded during hemodynamic interventions and cardiac arrest. Analyses included Pearson’s r, Wilcoxon rank-sum test, and BVAR. Intraosseous pressure showed correlating pulsatility with arterial pressure, ranging from 9 to 71% of mean arterial pressure. Correlation was strong under normal conditions (r = 0.75–0.96, p < 0.001) and during CPR (r = 0.65–0.99, p < 0.001), weakened during asystole (r = 0.26 ± 0.46, p < 0.001), and was disrupted by epinephrine (r = 0.04, p < 0.001). Asystole was identifiable on intraosseous tracings. Intraosseous pressure effectively reflects circulatory activity and may aid in accurately identifying asystole with possible clinical implications for CPR.

The online version contains supplementary material available at 10.1007/s12265-025-10719-7.